Erik Fredlund
Science for Life Laboratory
40 Papers
395 Citations
Erik Fredlund is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Neuroblastoma & Biology. The author has an hindex of 28, co-authored 40 publications. Previous affiliations of Erik Fredlund include Karolinska Institutet & University of California, San Francisco.
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Papers
Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development
Paulina Kucharzewska,Helena C. Christianson,Johanna E. Welch,Katrin J. Svensson,Erik Fredlund,Markus Ringnér,Matthias Mörgelin,Erika Bourseau-Guilmain,Johan Bengzon,Mattias Belting +9 more
TL;DR: It is shown that the proteome and mRNA profiles of exosome vesicles closely reflect the oxygenation status of donor glioma cells and patient tumors, and that the exosomal pathway constitutes a potentially targetable driver of hypoxia-dependent intercellular signaling during tumor development.
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.
Linda Holmquist-Mengelbier,Erik Fredlund,Tobias Löfstedt,Rosa Noguera,Samuel Navarro,Helén Nilsson,Alexander Pietras,Johan Vallon-Christersson,Åke Borg,Katarina Gradin,Lorenz Poellinger,Sven Påhlman +11 more
TL;DR: High HIF-2alpha protein levels were correlated with advanced clinical stage and high VEGF expression and predicted poor prognosis in a clinical neuroblastoma material and have general tumor biological implications.
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GOBO: Gene Expression-Based Outcome for Breast Cancer Online.
TL;DR: A multifunctional user-friendly online tool, GOBO is described, allowing a range of different analyses to be performed in an 1881-sample breast tumor data set, and a 51- sample breast cancer cell line set, both generated on Affymetrix U133A microarrays.
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
Hsin-Yu Fang,Russell Hughes,Craig Murdoch,Seth B. Coffelt,Subhra K. Biswas,Adrian L. Harris,Randall S. Johnson,Hongxia Z. Imityaz,M. Celeste Simon,Erik Fredlund,Florian R. Greten,Jordi Rius,Claire E. Lewis +12 more
TL;DR: It is shown that both HIF-1 and -2, but not NF-kappaB, are important transcriptional effectors regulating the responses of macrophages to such a period of hypoxia, and their role in the hypoxic induction of many of these key genes is elucidated.
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The mutational landscapes of genetic and chemical models of Kras -driven lung cancer
Peter M. K. Westcott,Kyle D. Halliwill,Minh D. To,Mamunur Rashid,Alistair G. Rust,Thomas M. Keane,Reyno Delrosario,Kuang-Yu Jen,Kay E. Gurley,Christopher J. Kemp,Erik Fredlund,David A. Quigley,David J. Adams,Allan Balmain +13 more
TL;DR: This article performed whole-exome sequencing on adenomas from three mouse models of non-small-cell lung cancer, which were induced either by exposure to carcinogens (methyl-nitrosourea (MNU) and urethane) or by genetic activation of Kras (Kras(LA2).