Renal cell carcinoma

In the United States, renal cancer is the 7th leading malignant condition in men and the 12th in women, accounting for 2.6 percent of all cancers. This article discusses the evolving presentation, understanding, and treatment of this disease.

https://www.pennstatehershey.org/c/document_library/get_file?uuid=258bd8b2-b869-424b-8706-11ea5edfb86a&groupId=101847

Renal-cell carcinoma.

Renal Mass and Localized Renal Cancer: AUA Guideline

Neurofibromatosis type 1 is a complex autosomal dominant disorder caused by germline mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis type 1 develop pigmentary lesions (cafe-au-lait macules, skinfold freckling and Lisch nodules) and dermal neurofibromas. Some individuals develop skeletal abnormalities (scoliosis, tibial pseudarthrosis and orbital dysplasia), brain tumours (optic pathway gliomas and glioblastoma), peripheral nerve tumours (spinal neurofibromas, plexiform neurofibromas and malignant peripheral nerve sheath tumours), learning disabilities, attention deficits, and social and behavioural problems, which can negatively affect quality of life. With the identification of NF1 and the generation of accurate preclinical mouse strains that model some of these clinical features, therapies that target the underlying molecular and cellular pathophysiology for neurofibromatosis type 1 are becoming available. Although no single treatment exists, current clinical management strategies include early detection of disease phenotypes (risk assessment) and biologically targeted therapies. Similarly, new medical and behavioural interventions are emerging to improve the quality of life of patients. Although considerable progress has been made in understanding this condition, numerous challenges remain; a collaborative and interdisciplinary approach is required to manage individuals with neurofibromatosis type1 and to develop effective treatments.

Neurofibromatosis type 1.

Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms that originate from endocrine glands such as the pituitary, the parathyroids, and the (neuroendocrine) adrenal, as well as endocrine islets within glandular tissue (thyroid or pancreatic) and cells dispersed between exocrine cells, such as endocrine cells of the digestive (gastroenteropancreatic) and respiratory tracts. Conventionally, NETs may present with a wide variety of functional or nonfunctional endocrine syndromes and may be familial and have other associated tumors. Assessment of specific or general tumor markers offers high sensitivity in establishing the diagnosis and can also have prognostic significance. Imaging modalities include endoscopic ultrasonography, computed tomography and magnetic resonance imaging, and particularly, scintigraphy with somatostatin analogs and metaiodobenzylguanidine. Successful treatment of disseminated NETs requires a multimodal approach; radical tumor surgery may be curative but is rarely possible. Well-differentiated and slow-growing gastroenteropancreatic tumors should be treated with somatostatin analogs or alpha-interferon, with chemotherapy being reserved for poorly differentiated and progressive tumors. Therapy with radionuclides may be used for tumors exhibiting uptake to a diagnostic scan, either after surgery to eradicate microscopic residual disease or later if conventional treatment or biotherapy fails. Maintenance of the quality of life should be a priority, particularly because patients with disseminated disease may experience prolonged survival.

/pdf/the-diagnosis-and-medical-management-of-advanced-5bw7heqxt0.pdf

The diagnosis and medical management of advanced neuroendocrine tumors.

Parenchymal sparing surgery in patients with hereditary renal cell carcinoma: 10-year experience

Renal cancer is diagnosed in about 28,800 Americans each year, and is responsible for more than 11,300 deaths per year (1). Renal cancer is most commonly diagnosed between the age of 50 and 70, and affects men twice as frequently as women (2). Environmental factors linked to the development of renal cancer include cigarette smoking, obesity, and exposure to asbestos, cadmium, or petrochemical products (3–8).

Molecular Genetics of Renal Cell Carcinoma

Purpose: We review the literature and characterize the clinical findings of von Recklinghausen’s associated pheochromocytoma. Materials and Methods: A Grateful Med search for the years 1966 to 1999 was performed on the subjects, “von Recklinghausen” and “neurofibromatosis.” Articles from the Grateful Med search were then reviewed to identify older publications. Of 325 articles 118 are included in this review. Results: Pheochromocytomas have been clinically identified in 0.1 to 5.7% of patients with von Recklinghausen’s disease. Mean patient age was 42 years (range 1.5 to 74) in 87 women and 61 men at presentation with pheochromocytoma. Of the 148 patients 84% had solitary adrenal tumors, 9.6% bilateral adrenal disease and 6.1% ectopic pheochromocytomas. Symptoms related to pheochromocytoma or hypertension were noted in 78% of the patients. Tumors secreted epinephrine and norepinephrine, and 87% demonstrated metaiodobenzylguanidine uptake. Of the 148 patients 6% died during pregnancy or a medical procedure, or due to hypertensive crisis without apparent provocation, 8.8% had gastrointestinal carcinoid tumors and 11.5% had metastases or local invasion from pheochromocytoma. Conclusions: Pheochromocytomas occur in a small but defined number of patients with von Recklinghausen’s disease, and can be associated with significant morbidity and mortality if not detected. Screening of patients with von Recklinghausen’s disease and hypertension or before provocative procedures or pregnancy seems to be indicated. Clinical diagnosis of von Recklinghausen’s disease is made based on 2 or more signs of 6 or more cafh au lait spots, 2 or more neurofibromas or 1 plexifom neurofibroma, axillary or inguinal freckling, optic glioma, 2 or more Lisch nodules (hamartomas of the iris), osseous lesions (sphenoid dysplasia, pseudarthrosis or scoliosis) or 1 sign and a first degree affected relative.’ Patients with von Recklinghausen’s disease are less commonly predisposed to have neurofibroma with sarcomatoid degeneration, brain tumors, optic glioma, islet cell tumors or arterial dysplasia with vascular stenosis and hyperten~ion.~-~ Von Recklinghausen’s disease is inherited in an autosomal dominant fashion and has been estimated to occur in 1/3,000 birth^.^ In 1910 Suzuki first recognized the association of pheochromocytomas with von Recklinghausen’s disease.6 Historical review of families with this disease identified a 0.1 to 5.7% incidence of pheochrom~cytomas.~~~*~-~~ Pheochromo

Review Article VON RECKLINGHAUSEN'S DISEASE AND PHEOCHROMOCYTOMAS

von Recklinghausen's disease and pheochromocytomas.

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Erik Enquist

Author Tools

Chat about Author

Papers

Parenchymal sparing surgery in patients with hereditary renal cell carcinoma: 10-year experience

Molecular Genetics of Renal Cell Carcinoma

Review Article VON RECKLINGHAUSEN'S DISEASE AND PHEOCHROMOCYTOMAS

von Recklinghausen's disease and pheochromocytomas.