Ericka A. Becker
University of Wisconsin-Madison
14 Papers
25 Citations
Ericka A. Becker is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Simian immunodeficiency virus & Cytotoxic T cell. The author has an hindex of 13, co-authored 14 publications.
Chat about Author
Papers
MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques.
Shelby L. O’Connor,Jennifer J. Lhost,Ericka A. Becker,Ann M. Detmer,Randall C. Johnson,Randall C. Johnson,Caitlin E. MacNair,Roger W. Wiseman,Julie A. Karl,Justin M. Greene,Benjamin J. Burwitz,Benjamin N. Bimber,Simon M. Lank,Jennifer J. Tuscher,Edward T. Mee,Nicola J. Rose,Ronald C. Desrosiers,Austin L. Hughes,Thomas C. Friedrich,Mary Carrington,Mary Carrington,David H. O’Connor +21 more
TL;DR: This manuscript demonstrates unambiguous major histocompatibility complex heterozygote advantage in macaque monkeys infected with the same strain of simian immunodeficiency virus, suggesting that a prophylactic HIV vaccine should elicit a population of CD8+ T cells with broad specificity.
Whole-Genome Characterization of Human and Simian Immunodeficiency Virus Intrahost Diversity by Ultradeep Pyrosequencing
Benjamin N. Bimber,Dawn M. Dudley,Michael Lauck,Ericka A. Becker,Emily N. Chin,Simon M. Lank,Haiying Li Grunenwald,Nicholas Caruccio,Mark Maffitt,Nancy A. Wilson,Jason S. Reed,James M. Sosman,Leandro F. Tarosso,Sabri Saeed Sanabani,Esper G. Kallas,Austin L. Hughes,David H. O’Connor +16 more
TL;DR: This work used ultradeep pyrosequencing to sequence complete HIV/SIV genomes, detecting variants present at a frequency as low as 1% and revealing low-level drug resistance and detecting previously hidden changes in the viral population.
Specific CD8+ T cell responses correlate with control of simian immunodeficiency virus replication in Mauritian cynomolgus macaques.
Melisa L. Budde,Justin M. Greene,Emily N. Chin,Adam J. Ericsen,Matthew Scarlotta,Brian T Cain,Ngoc H Pham,Ericka A. Becker,Max Harris,Jason T. Weinfurter,Shelby L. O’Connor,Michael Piatak,Jeffrey D. Lifson,Emma Gostick,David Price,Thomas C. Friedrich,David H. O’Connor +16 more
TL;DR: Results suggest that the T cell-mediated control of virus replication that is observed is more likely the consequence of targeting specificity rather than T cell breadth.
63
MHC class I characterization of Indonesian cynomolgus macaques.
Chad J. Pendley,Ericka A. Becker,Julie A. Karl,Alex J. Blasky,Roger W. Wiseman,Austin L. Hughes,Shelby L. O’Connor,David H. O’Connor +7 more
TL;DR: A better understanding of the MHC class I alleles present in Indonesian cynomolgus macaques improves their value as a model for disease research, and it better defines the biogeography of cynomlgus Macaca fascicularis throughout Southeast Asia.
Transcriptionally Abundant Major Histocompatibility Complex Class I Alleles Are Fundamental to Nonhuman Primate Simian Immunodeficiency Virus-Specific CD8+ T Cell Responses
Melisa L. Budde,Jennifer J. Lhost,Benjamin J. Burwitz,Ericka A. Becker,Charles M. Burns,Shelby L. O’Connor,Julie A. Karl,Roger W. Wiseman,Benjamin N. Bimber,Guang Lan Zhang,William H. Hildebrand,Vladimir Brusic,David H. O’Connor +12 more
TL;DR: Results suggest that transcriptionally abundant MHC-I transcripts are principally responsible for restricting SIV-specific CD8+ T cell responses, and that only a subset of the thousands of known M HC-I alleles in macaques should be prioritized for CD8- T cell epitope characterization.
52