25 Papers
21 Citations
Erica Lynn is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 10 publications. Previous affiliations of Erica Lynn include University of Texas at Austin.
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Papers
Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure
Kadir C. Akdemir,Victoria T. Le,Justin M. Kim,Justin M. Kim,Sarah Killcoyne,Sarah Killcoyne,Devin A. King,Ya-Ping Lin,Yanyan Tian,Akira Inoue,Samirkumar B. Amin,Frederick S. Robinson,Manjunath Nimmakayalu,Rafael E. Herrera,Erica Lynn,Kin Chan,Kin Chan,Sahil Seth,Leszek J. Klimczak,Moritz Gerstung,Dmitry A. Gordenin,John P. O'Brien,Lei Li,Yonathan Lissanu Deribe,Roel G.W. Verhaak,Peter J. Campbell,Rebecca C. Fitzgerald,Ashby J. Morrison,Jesse R. Dixon,P. Andrew Futreal +29 more
TL;DR: The analyses reveal that the change in somatic mutational load in cancer genomes is co-localized with topologically-associating-domain boundaries, and the interplay between three-dimensional genome organization and active mutational processes has a substantial influence on the large-scale mutation-rate variations observed in human cancers.
A surge of DNA damage links transcriptional reprogramming and hematopoietic deficit in Fanconi anemia
Xi Shen,Rui Wang,Moon Jong Kim,Qianghua Hu,Chih Chao Hsu,Jun Yao,Naeh L. Klages-Mundt,Yanyan Tian,Erica Lynn,Thomas F. Brewer,Yilei Zhang,B. K. Arun,Boyi Gan,Michael Andreeff,Shunichi Takeda,Junjie Chen,Jae Il Park,Xiaobing Shi,Christopher J. Chang,Sung Yun Jung,Jun Qin,Lei Li,Lei Li +22 more
TL;DR: The results demonstrate that rapid and extensive transcription reprogramming associated with hematopoietic differentiation poses a major threat to genome stability and cell viability in the absence of the FA pathway.
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The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks
Qianghua Hu,Naeh L. Klages-Mundt,Rui Wang,Erica Lynn,Liton Kuma Saha,Huimin Zhang,Mrinal Srivastava,Xi Shen,Yanyan Tian,Hyeung Kim,Yin Ye,Tanya T. Paull,Shunichi Takeda,Junjie Chen,Lei Li +14 more
TL;DR: A sensitive and versatile assay, designated ARK, for the quantitative analysis of DPCs in cells and it is shown that the Fanconi anemia pathway contributes to the repair of D PCs.
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DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress.
Rui Wang,Walter F. Lenoir,Walter F. Lenoir,Chao Wang,Dan Su,Megan McLaughlin,Qianghua Hu,Xi Shen,Yanyan Tian,Naeh L. Klages-Mundt,Naeh L. Klages-Mundt,Erica Lynn,Richard D. Wood,Richard D. Wood,Junjie Chen,Junjie Chen,Traver Hart,Traver Hart,Lei Li,Lei Li,Lei Li +20 more
TL;DR: In this paper, a comprehensive genome-wide profile of FA pathway synthetic lethality, including the function of DNA polymerase iota (Pol ι), was found to play a critical role in DNA repair and replication fork restart.
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Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers
Lauren E. Colbert,Molly B. El Alam,Erica Lynn,Julianna K. Bronk,Tatiana Karpinets,X. Wu,B. Chapman,Travis T. Sims,D J Lin,Ramez Kouzy,Julie Sammouri,Greyson Biegert,Andrea Y. Delgado Medrano,Adilene Olvera,Jairam Sastry,Patricia J. Eifel,Anjua Jhingran,Li Lin,Lois M. Ramondetta,P. Andrew Futreal,Amir A. Jazaeri,Kathleen M. Schmeler,J. Yue,A. Mitra,Kyoko Yoshida-Court,John P. Wargo,Travis Solley,V. Hedge,Sita Nookala,Ananta V. Yanamandra,S. Dorta-Estamera,Geena Mathew,R. Kavukuntla,C. Papso,Mustapha Ahmed-Kaddar,M. Kim,J. Zhang,A. Reuben,E. Holliday,Bernard Minsky,A. A. Koong,Eugene J. Koay,Prerna Das,Cassio Taniguchi,Ann H. Klopp +44 more
TL;DR: In HPV16+ patients, improved recurrence-free survival was associated with HPV-responsive T-cell expansion during chemoradiotherapy, and this work lays the groundwork for understanding radiation-induced immune response among other cancers.
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