Eric Weber
Novartis
9 Papers
134 Citations
Eric Weber is an academic researcher from Novartis. The author has contributed to research in topics: Elongation factor & Mutant. The author has an hindex of 5, co-authored 8 publications.
Chat about Author
Papers
Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.
Rowan P. Morris,Jennifer A. Leeds,Hans Ulrich Naegeli,Lukas Oberer,Klaus Memmert,Eric Weber,Matthew J. LaMarche,Christian N. Parker,Nathalie Burrer,Stacey Esterow,Andreas Hein,Esther K. Schmitt,Philipp Krastel +12 more
TL;DR: The thiomuracins are a novel family of thiopeptides produced by a rare-actinomycete bacterium typed as a Nonomuraea species that have a low propensity for selecting for antibiotic resistance and confer no measurable cross-resistance to antibiotics in clinical use.
176
Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties
Philipp Krastel,Silvio Roggo,Markus Schirle,Nathan T. Ross,Francesca Perruccio,Peter Aspesi,Thomas Aust,Kathrin Buntin,David Estoppey,Brigitta Liechty,Felipa A. Mapa,Klaus Memmert,Howard R Miller,Xuewen Pan,Ralph Riedl,Christian Thibaut,Jason R. Thomas,Trixie Wagner,Eric Weber,Xiaobing Xie,Esther K. Schmitt,Dominic Hoepfner +21 more
TL;DR: Biochemical and genetic evidence support an overlapping binding site of 1 with the anti-cancer compound didemnin B on EF-1α, and this myxobacterial chemotype offers an interesting starting point for further investigations of the potential of therapeutics targeting elongation factor 1.
103
Optimisation of protein expression and establishment of the Wave Bioreactor for Baculovirus/insect cell culture.
TL;DR: The set-up and the optimisation of parameters essential for successful operation and growth of insect cells to high cell densities in the Wave Bioreactor are described and a rapid and simple protocol for assessing expression and production conditions for the Baculovirus/insect cell system applicable to many different genes/proteins is developed.
A semi-automated large-scale process for the production of recombinant tagged proteins in the Baculovirus expression system.
Jean-Marc Schlaeppi,Mario Henke,Marion Mahnke,Steffen Hartmann,Rita Schmitz,Yann Pouliquen,Brendan Kerins,Eric Weber,Frank Kolbinger,Hans P. Kocher +9 more
TL;DR: This work has developed an integrated large-scale process for continuous and partially automated protein production in the Baculovirus system and has been validated with 41 His-tagged proteins with molecular weights ranging from 20 to 160 kDa.
31
Catching the Wave: The BEVS and the Biowave
Wilfried Weber,Eric Weber,Sabine Geisse,Klaus Memmert +3 more
- 01 Jan 2001
TL;DR: An optimised approach using the BEVS in conjunction with cultivation of insect cells at high cell density in the novel Wave bioreactor is reported on.
7