Eric S. Werdin
University of North Carolina at Chapel Hill
14 Papers
241 Citations
Eric S. Werdin is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Kidney disease & Cancer. The author has an hindex of 10, co-authored 14 publications. Previous affiliations of Eric S. Werdin include Tengion.
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Papers
Tubular cell-enriched subpopulation of primary renal cells improves survival and augments kidney function in rodent model of chronic kidney disease
Rusty Kelley,Eric S. Werdin,Andrew T. Bruce,Sumana Choudhury,Shay M. Wallace,Roger M. Ilagan,Bryan R. Cox,Patricia Tatsumi-Ficht,Elias A. Rivera,Thomas Spencer,H. Scott Rapoport,Belinda J. Wagner,Kelly I. Guthrie,Manuel J. Jayo,Timothy A. Bertram,Sharon C. Presnell +15 more
TL;DR: The effect of kidney cells, delivered orthotopically by intraparenchymal injection to rodents 4-7 wk after CKD was established by two-step 5/6 renal mass reduction (NX), on the regeneration of kidney function and architecture as assessed by physiological, tissue, and molecular markers is evaluated.
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Short-Term Human Prostate Primary Xenografts An in Vivo Model of Human Prostate Cancer Vasculature and Angiogenesis
Danny R. Gray,Wendy J. Huss,Jeffrey M. Yau,Lori E. Durham,Eric S. Werdin,William K. Funkhouser,Gary J. Smith +6 more
TL;DR: It is reported that primary xenografts of human CaP and of noninvolved areas of the human prostate peripheral zone transplanted to athymic nude mice provide a unique model of human angiogenesis occurring in an intact human prostate tissue microenvironment and for comparison ofAngiogenesis in CaP versus benign prostate.
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Evidence of pluripotent human prostate stem cells in a human prostate primary xenograft model.
TL;DR: The phenotypic plasticity of the human prostate stem cell within human prostate tissue was examined to determine the response of the stem cell to changes in the androgenic environment.
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Isolation, characterization, and expansion methods for defined primary renal cell populations from rodent, canine, and human normal and diseased kidneys.
Sharon C. Presnell,Andrew T. Bruce,Shay M. Wallace,Sumana Choudhury,Christopher W. Genheimer,Bryan R. Cox,Kelly I. Guthrie,Eric S. Werdin,Patricia Tatsumi-Ficht,Roger M. Ilagan,Russell W. Kelley,Elias A. Rivera,John W. Ludlow,Belinda J. Wagner,Manuel J. Jayo,Timothy A. Bertram +15 more
TL;DR: Methods that yield distinct subpopulations of primary kidney cells that are compatible with process development and scale-up are developed, suggesting that autologous sourcing of cells that contribute to in situ kidney regeneration after injury is feasible, even with biopsies from patients with advanced CKD.
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Establishment of short-term primary human prostate xenografts for the study of prostate biology and cancer.
TL;DR: The development of this methodology, including the technique for cryopreservation of human tissue, will allow multiple (successive) analyses of human prostate tissue to be conducted throughout time using a tissue sample derived from a single patient; and simultaneous analysis ofhuman prostate tissuesderived from a cohort of patients.