Eric M. Slimko
California Institute of Technology
16 Papers
287 Citations
Eric M. Slimko is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Aeroshell & Mars Exploration Program. The author has an hindex of 9, co-authored 16 publications.
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Papers
SMAP L-Band Microwave Radiometer: Instrument Design and First Year on Orbit
Jeffrey R. Piepmeier,Paolo Focardi,Kevin Horgan,Joseph Knuble,Negar Ehsan,Jared Lucey,C. Brambora,Paula R. Brown,Pamela Hoffman,Richard French,Rebecca Mikhaylov,Eug-Yun Kwack,Eric M. Slimko,Douglas Dawson,Derek Hudson,Jinzheng Peng,Priscilla N. Mohammed,Giovanni De Amici,Adam P. Freedman,James Medeiros,Fred Sacks,Robert H. Estep,Michael W. Spencer,Curtis W. Chen,K. Wheeler,W. Edelstein,Peggy O'Neill,Eni G. Njoku +27 more
TL;DR: The SMAP radiometer electronics are thermally controlled to achieve good radiometric stability, and analyses of on-orbit results indicate that the electrical and thermal characteristics of the electronics and internal calibration sources are very stable and promote excellent gain stability.
Selective Electrical Silencing of Mammalian Neurons In Vitro by the Use of Invertebrate Ligand-Gated Chloride Channels
TL;DR: The experiments demonstrate the feasibility of using invertebrate ligand-activated Cl− channels as an approach to modulate excitability and provide an in vitromodel mimicking conditions that can be obtained in transgenic mice and in viral-mediated gene therapy.
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Reversible silencing of neuronal excitability in behaving mice by a genetically targeted, ivermectin-gated Cl- channel.
Walter Lerchner,Cheng Xiao,Raad Nashmi,Eric M. Slimko,Laurent van Trigt,Henry A. Lester,David J. Anderson +6 more
TL;DR: The two-subunit GluCl/IVM system permits "intersectional" strategies designed to increase the cellular specificity of silencing in transgenic animals, and in striatal slice preparations from GLUClalphabeta-expressing animals, IVM rapidly suppressed spiking.
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Tyrosine Decaging Leads to Substantial Membrane Trafficking during Modulation of an Inward Rectifier Potassium Channel
Yanhe Tong,Gabriel S. Brandt,Ming Li,George Shapovalov,Eric M. Slimko,Andreas Karschin,Dennis A. Dougherty,Henry A. Lester +7 more
TL;DR: Decaging of a single tyrosine residue in a single species of membrane protein leads to massive clathrin-mediated endocytosis; these data establish that side chain decaging can provide valuable time-resolved data about intracellular signaling systems.
Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel
TL;DR: The modified GluCl channel, without glutamate sensitivity but with a fluorescent tag, may be more useful in Glu Cl silencing strategies, and no significant functional difference was found between these XFP‐tagged receptors and WT receptors.
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