30 Papers
160 Citations
Eric Lau is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Biology & Cancer research. The author has an hindex of 16, co-authored 21 publications. Previous affiliations of Eric Lau include University of California, San Diego.
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Papers
Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies.
Young Joo Jeon,Sihem Khelifa,Boris I. Ratnikov,David A. Scott,Yongmei Feng,Fabio Parisi,Chelsea Ruller,Eric Lau,Hyungsoo Kim,Laurence M. Brill,Tingting Jiang,David L. Rimm,Robert D. Cardiff,Gordon B. Mills,Jeffrey W. Smith,Andrei L. Osterman,Yuval Kluger,Ze'ev Ronai +17 more
TL;DR: Regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 by the ubiquitin ligase RNF5 underlies BCa response to chemotherapies and indicates positive prognosis in BCa.
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ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease.
TL;DR: An overview of the currently known upstream regulators and downstream targets of ATF2 is provided to provide insights into fundamental regulatory mechanisms that influence how cells integrate extracellular and intracellular signals into a genomic response through transcription factors.
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Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy
Christopher P. Vellano,Michael G. White,Miles C. Andrews,Manoj Chelvanambi,Russell Witt,Joseph R. Daniele,Mark Titus,Jennifer L. McQuade,Fabio Conforti,Elizabeth M. Burton,Matthew J. Lastrapes,Gabriel Ologun,Alexandria P. Cogdill,Golnaz Morad,Peter A. Prieto,Alexander J. Lazar,Yan-Jun Chu,Guangchun Han,M.A. Wadud Khan,Beth A. Helmink,Michael Davies,Rodabe N. Amaria,Jeffrey J. Kovacs,Scott E. Woodman,Sapna Pradyuman Patel,Patrick Hwu,Michael Peoples,Jeffrey E. Lee,Zachary A. Cooper,Haifeng Zhu,Guang Gao,Hiya Banerjee,M. Lau,Jeffrey E. Gershenwald,Anthony Lucci,Emily Z. Keung,Merrick I. Ross,Laura Pala,Eleonora Pagan,Rossana Lazcano Segura,Qian Liu,Mikayla S. Borthwick,Eric Lau,Melinda S. Yates,Shannon N. Westin,Khalida Wani,Michael T. Tetzlaff,Lauren E. Haydu,Mikhila Mahendra,Xiaoyan Ma,Christopher J. Logothetis,Zachary Kulstad,Sarah B. Johnson,Courtney W. Hudgens,Ningping Feng,Lorenzo Federico,Georgina V. Long,P. Andrew Futreal,Swathi Arur,Hussein Abdul-Hassan Tawbi,Amy E. Moran,Linghua Wang,Timothy P. Heffernan,Joseph R. Marszalek,Jennifer A. Wargo +64 more
TL;DR: In this article , a group of patients with melanoma who were treated with neoadjuvant BRAF/MEK-targeted therapy (NCT02231775 , n = 51) and observed significantly higher rates of major pathological response (MPR; ≤ 10% viable tumour at resection) and improved recurrence-free survival (RFS) in female versus male patients.
The Role of Dbf4/Drf1-Dependent Kinase Cdc7 in DNA-Damage Checkpoint Control
TL;DR: It is shown that the complex formation, chromatin association, and kinase activity of Ddk are not inhibited during the DNA-damage-induced S-phase checkpoint response in Xenopus egg extracts and mammalian cells, and this results indicate that Ddk functions as an upstream regulator to monitor S- phase checkpoint signaling.
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Berberine and Evodiamine Act Synergistically Against Human Breast Cancer MCF-7 Cells by Inducing Cell Cycle Arrest and Apoptosis.
TL;DR: Combination of berberine and evodiamine acts synergistically to suppress the proliferation of MCF-7 cells by inducing cell cycle arrest and apoptosis, illustrating the potential synergistic and combinatorial application of bioactive natural products.
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