Eric J. Ditzel
University of Arizona
5 Papers
10 Citations
Eric J. Ditzel is an academic researcher from University of Arizona. The author has contributed to research in topics: Arsenite & Fatty liver. The author has an hindex of 4, co-authored 5 publications.
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Papers
Effects of Arsenite Exposure during Fetal Development on Energy Metabolism and Susceptibility to Diet-Induced Fatty Liver Disease in Male Mice.
TL;DR: In utero and continuous early-life exposure to trivalent arsenic disrupted normal metabolism and elevated the risk for fatty liver disease in mice maintained on a high-fat diet, suggesting individuals exposed to AsIII during key developmental periods and who remain exposed on the background of a Western-style diet may be at increased risk for metabolic disease later in life.
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From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration
Aram B. Cholanians,Andy Phan,Eric J. Ditzel,Todd D. Camenisch,Serrine S. Lau,Terrence J. Monks +5 more
TL;DR: The findings suggest that susceptible individuals may be at higher risk of developing synucleinopathies and/or neurodegeneration due to environmental As exposure and possibly leads to compensatory mechanisms leading to an increase in TH expression.
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Altered Hepatic Transport by Fetal Arsenite Exposure in Diet‐Induced Fatty Liver Disease
Eric J. Ditzel,Hui Li,Caroline E. Foy,Alec B. Perrera,Patricia Parker,Benjamin J. Renquist,Nathan J. Cherrington,Todd D. Camenisch +7 more
TL;DR: Developmental exposure to arsenite leads to changes in hepatic transport which could increase the risk for ADRs during fatty liver disease, and murine embryonic hepatocytes and adult primary hepatocytes show significantly altered transporter expression after exposure to arsenic alone.
Arsenite Disrupts Zinc-Dependent TGFβ2-SMAD Activity During Murine Cardiac Progenitor Cell Differentiation.
TL;DR: Zinc partially protects cardiac EMT from developmental toxicity by arsenite, as Zn(2+) supplementation reverses the disruption in Smad2/3 nuclear translocation and transcriptional activity by arsenites.
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Methylation of inorganic arsenic by murine fetal tissue explants.
TL;DR: Investigating inorganic arsenic methylation by murine embryonic organ cultures of the heart, lung, and liver found mRNA for AS3mt, the gene responsible for methylation of arsenic, was detected in all embryonic tissue types studied.
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