Eric H. Raabe
Johns Hopkins University School of Medicine
136 Papers
195 Citations
Eric H. Raabe is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Cancer research & Biology. The author has an hindex of 26, co-authored 89 publications. Previous affiliations of Eric H. Raabe include Children's Hospital of Philadelphia & New York University.
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Papers
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
Catherine S. Grasso,Yujie Tang,Yujie Tang,Nathalene Truffaux,Noah E. Berlow,Lining Liu,Marie-Anne Debily,Marie-Anne Debily,Michael J. Quist,Lara E. Davis,Elaine C. Huang,Pamelyn Woo,Anitha Ponnuswami,S. Chen,Tessa Johung,Wenchao Sun,Mari Kogiso,Yuchen Du,Lin Qi,Yulun Huang,Yulun Huang,Marianne Hütt-Cabezas,Katherine E. Warren,Ludivine Le Dret,Paul S. Meltzer,Hua Mao,Martha Quezado,Dannis G. van Vuurden,Jinu Abraham,Maryam Fouladi,Matthew N. Svalina,Nicholas J. Wang,Cynthia Hawkins,Javad Nazarian,Marta M. Alonso,Eric H. Raabe,Esther Hulleman,Paul T. Spellman,Xiao-Nan Li,Charles Keller,Ranadip Pal,Jacques Grill,Jacques Grill,Michelle Monje +43 more
TL;DR: Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects, and these data suggest a promising therapeutic strategy for DIPG.
Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors
Sharareh Gholamin,Sharareh Gholamin,Siddhartha Mitra,Abdullah H. Feroze,Jie Liu,Suzana Assad Kahn,Michael Zhang,Rogelio Esparza,Chase Richard,Vijay Ramaswamy,Marc Remke,Marc Remke,Anne Kathrin Volkmer,Anne Kathrin Volkmer,Stephen B. Willingham,Anitha Ponnuswami,Aaron McCarty,Patricia Lovelace,Theresa A. Storm,Simone Schubert,Gregor Hutter,Cyndhavi Narayanan,Pauline Chu,Eric H. Raabe,Griffith R. Harsh,Michael D. Taylor,Michelle Monje,Yoon Jae Cho,Ravi Majeti,Jens Peter Volkmer,Paul G. Fisher,Gerald A. Grant,Gary K. Steinberg,Hannes Vogel,Michael S. B. Edwards,Irving L. Weissman,Samuel H. Cheshier +36 more
TL;DR: The effect of a humanized anti-CD47 antibody, Hu5F9-G4, is demonstrated to be a potentially safe and effective therapeutic agent for managing multiple pediatric central nervous system malignancies.
372
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer
Francesca Petralia,Nicole Tignor,Boris Reva,Mateusz Koptyra,Shrabanti Chowdhury,Dmitry Rykunov,Azra Krek,Weiping Ma,Yuankun Zhu,Jiayi Ji,Anna Calinawan,Jeffrey R. Whiteaker,Antonio Colaprico,Vasileios Stathias,Tatiana Omelchenko,Xiaoyu Song,Pichai Raman,Yiran Guo,Miguel A. Brown,Richard G. Ivey,John Szpyt,Sanjukta Guha Thakurta,Marina A. Gritsenko,Karl K. Weitz,Gonzalo Lopez,Selim Kalayci,Zeynep H. Gümüş,Seungyeul Yoo,Felipe da Veiga Leprevost,Hui Yin Chang,Karsten Krug,Lizabeth Katsnelson,Ying Wang,Jacob J. Kennedy,Uliana J. Voytovich,Lei Zhao,Krutika S. Gaonkar,Brian Ennis,Bo Zhang,Valerie Baubet,Lamiya Tauhid,Jena Lilly,Jennifer Mason,Bailey Farrow,Nathan Young,Sarah Leary,Sarah Leary,Sarah Leary,Jamie Moon,Vladislav A. Petyuk,Javad Nazarian,Javad Nazarian,Nithin D. Adappa,James N. Palmer,Robert Lober,Samuel Rivero-Hinojosa,Liang-Bo Wang,Joshua M. Wang,Matilda Broberg,Rosalie K. Chu,Ronald J. Moore,Matthew E. Monroe,Rui Zhao,Richard D. Smith,Jun Zhu,Ana I. Robles,Mehdi Mesri,Emily S. Boja,Tara Hiltke,Henry Rodriguez,Bing Zhang,Eric E. Schadt,D. R. Mani,Li Ding,Antonio Iavarone,Maciej Wiznerowicz,Maciej Wiznerowicz,Stephan C. Schürer,Xi Chen,Allison Heath,Jo Lynne Rokita,Alexey I. Nesvizhskii,David Fenyö,Karin D. Rodland,Karin D. Rodland,Tao Liu,Steven P. Gygi,Amanda G. Paulovich,Adam C. Resnick,Phillip B. Storm,Brian R. Rood,Pei Wang,Alicia Francis,Allison M. Morgan,Angela Waanders,Angela N. Viaene,Anna Maria Buccoliero,Arul M. Chinnaiyan,Carina A. Leonard,Cassie Kline,Chiara Caporalini,Christopher R. Kinsinger,Chunde Li,David E. Kram,Derek Hanson,Elizabeth Appert,Emily Kawaler,Eric H. Raabe,Eric M. Jackson,Jeffrey P. Greenfield,Gabrielle S. Stone,Gad Getz,Gerald A. Grant,Guo Ci Teo,Ian F. Pollack,Jason E. Cain,Jessica B. Foster,Joanna J. Phillips,July E. Palma,Karen A. Ketchum,Kelly V. Ruggles,Lili Blumenberg,MacIntosh Cornwell,Mahdi Sarmady,Marcin J. Domagalski,Marcin Cieślik,Mariarita Santi,Marilyn M. Li,Matthew J. Ellis,Matthew A. Wyczalkowski,Meghan Connors,Mirko Scagnet,Nalin Gupta,Nathan Edwards,Nicholas A Vitanza,Olena Morozova Vaske,Oren J. Becher,Peter B. McGarvey,Ron Firestein,Sabine Mueller,Samuel G. Winebrake,Saravana M. Dhanasekaran,Shuang Cai,Sonia Partap,Tatiana Patton,Toan Le,Travis D. Lorentzen,Wenke Liu,William Bocik +148 more
TL;DR: This is the first large-scale proteogenomics analysis across traditional histological boundaries to uncover foundational pediatric brain tumor biology and inform rational treatment selection.
261
Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening
Grant L. Lin,Kelli M. Wilson,Michele Ceribelli,Benjamin Z. Stanton,Pamelyn Woo,Sara Kreimer,Elizabeth Y. Qin,Xiaohu Zhang,James Lennon,Surya Nagaraja,Patrick J. Morris,Michael Quezada,Shawn M. Gillespie,Damien Y. Duveau,Aleksandra M. Michalowski,Paul Shinn,Rajarshi Guha,Marc Ferrer,Carleen Klumpp-Thomas,Sam Michael,Crystal McKnight,Paras S. Minhas,Zina Itkin,Eric H. Raabe,Lu Chen,Reem A. Ghanem,Anna Geraghty,Lijun Ni,Katrin I. Andreasson,Nicholas A Vitanza,Katherine E. Warren,Craig J. Thomas,Michelle Monje +32 more
TL;DR: This study provides a comprehensive single-agent and combinatorial drug screen for DMG and identifies concomitant HDAC and proteasome inhibition as a promising therapeutic strategy that underscores underrecognized metabolic vulnerabilities in DMG.
216
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG
Lin Quan Sun,David W. Lee,Quangeng Zhang,Weihong Xiao,Eric H. Raabe,Alan K. Meeker,Dengshun Miao,David L. Huso,Robert J. Arceci +8 more
TL;DR: Support for this hypothesis is provided by demonstrating that the disruption of PASG (lsh), a SNF2-like factor that facilitates DNA methylation, causes global hypomethylation, developmental growth retardation and a premature aging phenotype.