Eric Gilson
Shanghai Jiao Tong University
58 Papers
117 Citations
Eric Gilson is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Telomere & Shelterin. The author has an hindex of 25, co-authored 58 publications. Previous affiliations of Eric Gilson include University of Naples Federico II & École Normale Supérieure.
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Papers
The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats
Thomas Simonet,Laure-Emmanuelle Zaragosi,Claude Philippe,Kevin Lebrigand,Clémentine Schouteden,Adeline Augereau,Adeline Augereau,Serge Bauwens,Jing Ye,Jing Ye,Marco Santagostino,Elena Giulotto,Frédérique Magdinier,Béatrice Horard,Pascal Barbry,Rainer Waldmann,Eric Gilson,Eric Gilson +17 more
TL;DR: It is proposed that TRF1 and TRF2 couple the functional state of telomeres to the long-range organization of chromosomes and gene regulation networks by binding to extratelomeric sequences.
Telomeres and the functional architecture of the nucleus
TL;DR: This review focuses on cytological evidence for these interactions and on recent insights into the molecular organization of the telomeric complex, which can interact with other telosomes and with the nuclear envelope.
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Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells.
Joe Nassour,Sébastien Martien,Nathalie Martin,Emeric Deruy,Elisa Tomellini,Nicolas Malaquin,Fatima Bouali,Laure Sabatier,Nicolas Wernert,Sébastien Pinte,Sébastien Pinte,Eric Gilson,Albin Pourtier,Olivier Pluquet,Corinne Abbadie +14 more
TL;DR: It is shown that unlike fibroblasts, senescent epithelial cells do not activate an ATM-or ATR-dependent DNA damage response (DDR), but accumulate oxidative-stress-induced DNA single-strand breaks (SSBs) which could fuel the very first steps of carcinogenesis.
The Wilms’ tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression
Kay-Dietrich Wagner,Julien Cherfils-Vicini,Naoki Hosen,Peter Hohenstein,Eric Gilson,Nicholas D. Hastie,Jean-François Michiels,Nicole Wagner +7 more
TL;DR: It is shown that endothelial, haematopoietic and myeloid-derived suppressor cells frequently express the Wilms' tumour suppressor Wt1, which transcriptionally controls expression of Pecam-1 and c-kit and is an important regulator of cancer growth via modulation of tumour vascularization, immune response and metastasis formation.
The Telomeric Protein TRF2 Regulates Angiogenesis by Binding and Activating the PDGFRβ Promoter
Mounir El Maï,Kay-Dietrich Wagner,Jean-François Michiels,Damien Ambrosetti,Arnaud Borderie,Sandrine Destree,Valerie Renault,Nadir Djerbi,Marie-Josèphe Giraud-Panis,Eric Gilson,Nicole Wagner +10 more
TL;DR: It is revealed here that TRF2 is expressed in the vasculature of most human cancer types, where it colocalizes with the Wilms' tumor suppressor WT1 and is required for proliferation, migration, and tube formation of endothelial cells.
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