15 Papers
167 Citations
Eric Frapy is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Francisella tularensis & Neisseria meningitidis. The author has an hindex of 14, co-authored 15 publications. Previous affiliations of Eric Frapy include Paris Descartes University.
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Papers
The Plasmid of Escherichia coli Strain S88 (O45:K1:H7) That Causes Neonatal Meningitis Is Closely Related to Avian Pathogenic E. coli Plasmids and Is Associated with High-Level Bacteremia in a Neonatal Rat Meningitis Model
Chantal Peigne,Philippe Bidet,Farah Mahjoub-Messai,Céline Plainvert,Valérie Barbe,Claudine Médigue,Eric Frapy,Xavier Nassif,Erick Denamur,Edouard Bingen,Stéphane Bonacorsi +10 more
TL;DR: The sequence, epidemiology and function of the large plasmid harbored by strain S88, which is representative of the O45:K1 clonal group, are described and it is shown that a pS88-like plasmids is present in other meningitis clonal groups and in avian pathogenic strains and human urosepsis strains belonging to subgroup B21.
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Role of the wbt Locus of Francisella tularensis in Lipopolysaccharide O-Antigen Biogenesis and Pathogenicity
Catherine Raynaud,Catherine Raynaud,Karin L. Meibom,Karin L. Meibom,Marie-Annick Lety,Marie-Annick Lety,Iharilalao Dubail,Iharilalao Dubail,Thomas Candela,Eric Frapy,Eric Frapy,Alain Charbit,Alain Charbit +12 more
TL;DR: Inactivation of wbtA led to the complete loss of O antigen, conferred serum sensitivity, impaired intracellular replication, and severely attenuated virulence in the mouse model, ensuring protection against a challenge against virulent LVS.
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Asparagine assimilation is critical for intracellular replication and dissemination of Francisella.
Gael Gesbert,Gael Gesbert,Elodie Ramond,Elodie Ramond,Mélanie Rigard,Mélanie Rigard,Eric Frapy,Eric Frapy,Marion Dupuis,Marion Dupuis,Iharilalao Dubail,Iharilalao Dubail,Monique Barel,Monique Barel,Thomas Henry,Thomas Henry,Karin L. Meibom,Karin L. Meibom,Alain Charbit,Alain Charbit +19 more
TL;DR: This work unravels thus, for the first time, the importance of asparagine for cytosolicmultiplication of Francisella and indicates that Amino acid transporters are likely to constitute underappreciated players in bacterial intracellular parasitism.
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Importance of branched-chain amino acid utilization in Francisella intracellular adaptation
Gael Gesbert,Elodie Ramond,Elodie Ramond,Fabiola Tros,Fabiola Tros,Julien Dairou,Eric Frapy,Eric Frapy,Monique Barel,Monique Barel,Alain Charbit,Alain Charbit +11 more
TL;DR: The data presented establish the importance of isoleucine utilization for efficient phagosomal escape and cytosolic multiplication of Francisella and suggest that virulent F. tularensis subspecies have lost their branched-chain amino acid biosynthetic pathways and rely exclusively on dedicated uptake systems.
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A two-component system is required for colonization of host cells by meningococcus.
Anne Jamet,Anne Jamet,Clotilde Rousseau,Clotilde Rousseau,Jean-Benoît Monfort,Jean-Benoît Monfort,Eric Frapy,Eric Frapy,Xavier Nassif,Xavier Nassif,Xavier Nassif,Patricia Martin,Patricia Martin +12 more
TL;DR: Evidence is provided that one of the four TCSs existing in N. meningitidis contributes to the adaptation of the pathogen to growth on host cells.
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