Eric Denbaum
New York University
7 Papers
Eric Denbaum is an academic researcher from New York University. The author has contributed to research in topics: Biology & Guanine nucleotide exchange factor. The author has an hindex of 3, co-authored 4 publications.
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Papers
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Sarah E Garnish,Sarah E Garnish,Yanxiang Meng,Yanxiang Meng,Akiko Koide,Jarrod J. Sandow,Jarrod J. Sandow,Eric Denbaum,Annette V. Jacobsen,Annette V. Jacobsen,Wayland Yeung,Andre L. Samson,Andre L. Samson,Christopher R Horne,Christopher R Horne,Cheree Fitzgibbon,Samuel N. Young,Phoebe P. C. Smith,Andrew I. Webb,Andrew I. Webb,Emma J. Petrie,Emma J. Petrie,Joanne M Hildebrand,Joanne M Hildebrand,Natarajan Kannan,Peter E. Czabotar,Peter E. Czabotar,Shohei Koide,James M. Murphy,James M. Murphy +29 more
TL;DR: In this paper, the pseudokinase domain of MLKL was studied and the crystal structures of two synthetic binding proteins, Monobody-27 and 32, were found to undergo a large conformational change upon activation and disengagement from RIPK3.
The structural basis of promiscuity in small multidrug resistance transporters.
Ali A. Kermani,Christian B. Macdonald,Olive E. Burata,B. Ben Koff,Akiko Koide,Eric Denbaum,Shohei Koide,Randy B. Stockbridge +7 more
TL;DR: Using solid-supported membrane electrophysiology, it is found that promiscuous transport of hydrophobic substituted cations is a general feature of SMR transporters and the molecular basis for promiscuity is solved.
Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications
Claire Albert,Laura G. Bracaglia,Atsuko Koide,Jenna DiRito,Taras Lysyy,Louie Harkins,Christopher M. Edwards,O. Richfield,Julian Grundler,Kai Zhou,Eric Denbaum,G. Ketavarapu,T. Hattori,Sudhir Perincheri,J. Langford,A. Feizi,Danielle J. Haakinson,Sarah A. Hosgood,Michael L. Nicholson,Jordan S. Pober,W. Mark Saltzman,Sachie Koide,Gregory T. Tietjen +22 more
TL;DR: In this paper , a monobody adapter that presents antibodies on the NP surface in a manner that fully preserves their antigen-binding function was proposed. But achieving sufficient levels of NP targeting in human settings remains elusive.
Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis.
Imran Khan,Imran Khan,Catherine MarElia-Bennet,Catherine MarElia-Bennet,Julia E. Lefler,Julia E. Lefler,Mariyam Zuberi,Mariyam Zuberi,Eric Denbaum,Akiko Koide,Dean M. Connor,Ann-Marie Broome,Thierry Pécot,Thierry Pécot,Cynthia J. Timmers,Cynthia J. Timmers,Michael C. Ostrowski,Michael C. Ostrowski,Shohei Koide,John P. O'Bryan,John P. O'Bryan +20 more
TL;DR: In this paper, the α4-α5 interface of RAS was used to inhibit PDAC development using an immunocompetent orthotopic mouse model, and the results suggest that targeting the #x3B1;4-#x3b1;5 allosteric site of KRAS may represent a viable therapeutic approach for inhibiting KRAS-mutant pancreatic tumours.
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Abstract B023: Inhibition of RAS signaling and tumorigenesis through targeting novel vulnerabilities
Akiko Koide,Mariyam Zuberi,G. Ketavarapu,Eric Denbaum,Kai Wen Teng,J. Matthew Rhett,Russell Spencer-Smith,G. Aaron Hobbs,E. Ramsay Camp,Shohei Koide,John P. O'Bryan +10 more
TL;DR: Kahn et al. as mentioned in this paper developed several Monobodies and extensively characterized one of them, R15, which bound exclusively to the apo state of all three RAS isoforms but did not interact with nucleotide-loaded RAS.