Eric Conway
European Institute of Oncology
11 Papers
5 Citations
Eric Conway is an academic researcher from European Institute of Oncology. The author has contributed to research in topics: PRC2 & Chromatin. The author has an hindex of 7, co-authored 11 publications. Previous affiliations of Eric Conway include Trinity College, Dublin.
Chat about Author
Papers
Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression.
Simone Tamburri,Elisa Lavarone,Daniel Fernández-Pérez,Daniel Fernández-Pérez,Eric Conway,Marika Zanotti,Daria Manganaro,Diego Pasini,Diego Pasini +8 more
TL;DR: Using a fully catalytic inactive RING1B mutant, it is demonstrated that H2AK119ub1 deposition is essential to maintain PcG-target gene repression in embryonic stem cells (ESCs) and overall, the data place H3K27me3 deposition as a central hub that mounts P cG repressive machineries to preserve cell transcriptional identity.
302
PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation.
Evan Healy,Marlena Mucha,Eleanor Glancy,Darren J. Fitzpatrick,Eric Conway,Hannah K. Neikes,Craig Monger,Guido van Mierlo,Marijke P. Baltissen,Yoko Koseki,Michiel Vermeulen,Haruhiko Koseki,Adrian P. Bracken +12 more
TL;DR: It is shown that PRC2.1 and PRC1.2 share the majority of target genes in mouse embryonic stem cells and a model in which the specific accessory proteins within PRC 2.2 cooperate to direct H3K27me3 via both synergistic and independent mechanisms is supported.
169
The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells
Gundula Streubel,Ariane Watson,Sriganesh Jammula,Andrea Scelfo,Darren J. Fitzpatrick,Giorgio Oliviero,Rachel McCole,Eric Conway,Eleanor Glancy,Gian Luca Negri,Eugene T. Dillon,Kieran Wynne,Diego Pasini,Nevan J. Krogan,Adrian P. Bracken,Gerard Cagney +15 more
TL;DR: The endogenous interactomes of Ezh2 and Suz12 in embryonic stem cells are mapped and a model in which Nsd1 is a key modulator of PRC2 function required for regulating the demarcation of genome-wide H3K27me2 and H3k27me3 domains in ESCs is supported.
160
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
Eric Conway,Emilia Jerman,Evan Healy,Shinsuke Ito,Daniel Holoch,Giorgio Oliviero,Orla Deevy,Eleanor Glancy,Darren J. Fitzpatrick,Marlena Mucha,Ariane Watson,Alan M. Rice,Paul Chammas,Christine S. Huang,Indigo Pratt-Kelly,Yoko Koseki,Manabu Nakayama,Tomoyuki Ishikura,Gundula Streubel,Kieran Wynne,Karsten Hokamp,Aoife McLysaght,Claudio Ciferri,Luciano Di Croce,Gerard Cagney,Raphaël Margueron,Haruhiko Koseki,Adrian P. Bracken +27 more
TL;DR: PALI1/2 potentially link polycombs with transcriptional co-repressors in the regulation of cellular identity during development and in cancer.
147
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation.
Eric Conway,Federico Rossi,Daniel Fernández-Pérez,Eleonora Ponzo,Karin Johanna Ferrari,Marika Zanotti,Daria Manganaro,Simona Rodighiero,Simone Tamburri,Simone Tamburri,Diego Pasini,Diego Pasini +11 more
TL;DR: In this paper, the authors show that BAP1 restricts H2AK119ub1 deposition to Polycomb target sites, which increases the stability of Polycomb with their targets and prevents diffuse accumulation of H3K27me3.
64