Computer executable software and device for guiding brain activity training comprising: logic which takes data corresponding to activity measurements of one or more internal voxels of a brain and determines one or more members of the group consisting of: a) what next stimulus to communicate to the subject, b) what next behavior to instruct the subject to perform, c) when a subject is to be exposed to a next stimulus, d) when the subject is to perform a next behavior, e) one or more activity metrics computed from the measured activity, f) a spatial pattern computed from the measured activity, g) a location of a region of interest computed from the measured activity, h) performance targets that a subject is to achieve computed from the measured activity, i) a performance measure of a subject's success computed from the measured activity, j) a subject's position relative to an activity measurement instrument; and logic for communicating information based on the determinations to the subject in substantially real time relative to when the activity is measured.

Methods for physiological monitoring,training, exercise and regulation

A computer assisted method is provided for diagnosing the in condition of a subject associated with particular activation in one or more regions of interest, the method comprising: having the subject perform a behavior or have a perception adapted to selectively activate one or more regions of interest associated with the condition; measuring activity of the one or more regions of interest as the behavior is performed or the subject has the perception; diagnosing the condition associated with the one or more regions of interest based on the activity in response to the behavior or perception; performing an intervention; and repeating this process one or more times including repeating said behavior, said measuring of activity and said diagnosis at a later time; and observing changes between measurements that are associated with said intervention.

Methods for measurement and analysis of brain activity

The present invention comprises systems and methods for stimulating target tissue comprising a light source (10), an implantable light conducting lead (22A) coupled to said light source (10); and an an implantable light-emitter (25). The light source (10), lead (22A), and emitter (25) are used to provide a light stimulation to a target tissue.

Applications of the stimulation of neural tissue using light

The present invention relates to methods, software and systems for monitoring fluctuations in magnetic resonance signals. These methods may be used for measurements of the human brain and nervous system, and may be used for measuring electric currents and electromagnetic fields internal to an object. This method may include the use of a reference signal to accomplish differential recording of electromagnetic fields from two or more spatial locations.

Methods for measurement of magnetic resonance signal perturbations

A magnetic resonance antenna has at least five antenna elements, each of, which extends essentially radially from an inner element beginning to at least one outer element end with respect to a center axis. The antenna elements are at least magnetically coupled with one another.

Magnetic resonance antenna

An EPI pulse sequence is performed by an NMR system which acquires 128 images of the brain over a time interval during which the subject performs a function or is stimulated. The acquired time course NMR data is displayed in different ways for analysis. Four different methods for producing brain function images from the NMR data are described.

Time course MRI imaging of brain functions

A local RF and gradient coil for acquiring images of the human brain using fast NMR pulse sequences includes an end capped RF bird cage coil surrounded by a 3 axis gradient coil assembly. An RF shield is disposed between the RF coil and the gradient coils and it is divided into separate segments to reduce eddy currents induced by the changing gradient fields.

NMR local coil for brain imaging

Objective: To compare the effects of contact transscleral diode laser treatment and retinal cryotherapy on blood-retinal barrier integrity with the use of high-resolution magnetic resonance imaging techniques with constant infusion of gadolinium—diethylenetriaminepentaacetic acid (Gd-DTPA). Methods: Transscleral diode laser photocoagulation and retinal cryotherapy were used to treat equivalent areas of the inferior retinal periphery of pigmented rabbits. Magnetic resonance imaging time-course studies with measurement of signal enhancements due to Gd-DTPA leak-age were conducted 2 and 15 days following treatment. Results: Two days following treatment, cryotherapytreated eyes exhibited a mean (±SD) effective Gd-DTPA permeability coefficient of 4.6±0.8×10 −6 cm/s; in comparison, diode laser—treated eyes exhibited 1.6×1.4×10 −6 cm/s effective permeability. Significant decreases in the effective permeability were also noted 15 days after treatment in both groups. Conclusions: Transscleral contact probe diode laser photocoagulation induces less disruption of the blood-retinal barrier than does conventional cryotherapy. In addition, the continuous infusion method of Gd-DTPA delivery is a reliable and easily interpretable alternative to the commonly used bolus injection approach.

High-Resolution Magnetic Resonance Imaging Evaluation of Blood-Retinal Barrier Integrity Following Transscleral Diode Laser Treatment

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Time course MRI imaging of brain functions

NMR local coil for brain imaging

High-Resolution Magnetic Resonance Imaging Evaluation of Blood-Retinal Barrier Integrity Following Transscleral Diode Laser Treatment