Eric C. Freeman
University of Georgia
47 Papers
245 Citations
Eric C. Freeman is an academic researcher from University of Georgia. The author has contributed to research in topics: Bilayer & Membrane. The author has an hindex of 10, co-authored 43 publications. Previous affiliations of Eric C. Freeman include Virginia Tech & University of Pittsburgh.
Chat about Author
Papers
Modeling the proton sponge hypothesis: examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modeling.
TL;DR: The results of a computational study modeling osmotically driven endosome burst or the ‘proton sponge effect' are presented, which builds on previous cellular simulation efforts by linking the previous model with a sponge protonation model, then observing the impact on endosomal swelling and acidification.
Activation of bacterial channel MscL in mechanically stimulated droplet interface bilayers
Joseph S. Najem,Myles D. Dunlap,Ian Rowe,Eric C. Freeman,John W. Grant,Sergei Sukharev,Donald J. Leo +6 more
TL;DR: The first reconstitution and activation of the low-threshold V23T mutant of MscL in a DIB as a response to axial compressions of the droplets is reported, clarifying the principles of interconversion between bulk and surface forces in the DIB, and facilitates the measurements of fundamental membrane properties.
52
High Energy Density Nastic Materials: Parameters for Tailoring Active Response
TL;DR: In this paper, the effects of varying material design parameters, such as system geometry and membrane permeability, are considered to aid in the custom design of an active material appropriate to a given application.
31
A new approach for investigating the response of lipid membranes to electrocompression by coupling droplet mechanics and membrane biophysics.
Joyce El-Beyrouthy,Michelle M. Makhoul-Mansour,Graham Taylor,Stephen A. Sarles,Eric C. Freeman +4 more
TL;DR: A new method for quantifying lipid–lipid interactions within biomimetic membranes undergoing electrocompression is demonstrated by coupling droplet mechanics and membrane biophysics, highlighting that a previously unaccounted for energetic term is produced during compression, potentially reflecting changes in the lateral membrane structure.
31
Evaluation of bending modulus of lipid bilayers using undulation and orientation analysis.
TL;DR: This work provides greater insight into the numerical aspects of evaluating the bilayer bending modulus, provides validation for the orientation analysis technique, and explores differences in bending moduli based on differences in the lipid nanostructures.
24