The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Dual variable domain immunoglobulins and uses thereof

The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

Cancerous Disease Modifying Antibodies

Pseudokinases are members of the protein kinase superfamily but signal primarily through noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human diseases, yet they remain largely unexplored as drug targets owing to challenges associated with modulation of their biological functions. Our understanding of the structure and physiological roles of pseudokinases has improved substantially over the past decade, revealing intriguing similarities between pseudokinases and their catalytically active counterparts. Pseudokinases often adopt conformations that are analogous to those seen in catalytically active kinases and, in some cases, can also bind metal cations and/or nucleotides. Several clinically approved kinase inhibitors have been shown to influence the noncatalytic functions of active kinases, providing hope that similar properties in pseudokinases could be pharmacologically regulated. In this Review, we discuss known roles of pseudokinases in disease, their unique structural features and the progress that has been made towards developing pseudokinase-directed therapeutics.

Prospects for pharmacological targeting of pseudokinases

The present invention provides a novel class of monoclonal antibodies which bind ErbB3 receptor and inhibits various ErbB3 functions. For example, the antibodies described herein are capable of binding to ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor.

Antibodies against erbb3 and uses thereof

The present invention relates to bispecific antibodies against human ErbB-3 and against human c-Met, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

Bispecific anti-erbb-3/anti-c-met antibodies

The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.

Antibodies directed to her-3 and uses thereof

Provided herein are antigen binding proteins, e.g.,human and/or monoclonal antibodies that have affinity for heparin-binding epidermal growth factor-like growth factor (HB-EGF) and neutralize the biological functions of this growth factor.

Heparin-binding epidermal growth factor-like growth factor antigen binding proteins

La presente invention concerne des proteines de liaison qui se lient au HER-3, ainsi que des polynucleotides codant pour ces proteines. L'invention concerne egalement des vecteurs d'expression et des cellules hotes contenant ces vecteurs pour la production de la proteine de liaison de l'invention. En outre, l'invention concerne des compositions et des procedes de diagnostic et de traitement de maladies associees a la transduction du signal mediee par le HER-3 et/ou son ligand hereguline.

Anticorps dirigés contre le her-3 et leurs utilisations

Antigenbindende proteine mit affinität für den heparin-binding epidermal growth factor-like-wachstumsfaktor

Gegen her-3 gerichtete antikörper und verwendungen davon

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