Eric Bailey
University of Leicester
20 Papers
274 Citations
Eric Bailey is an academic researcher from University of Leicester. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 10, co-authored 14 publications.
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Papers
Hydroxyethylvaline adduct formation in haemoglobin as a biological monitor of cigarette smoke intake
Eric Bailey,Alan G. F. Brooks,Colin T. Dollery,Peter B. Farmer,Barry J. Passingham,Marcus A. Sleightholm,David Yates +6 more
TL;DR: The HOEtVal adduct levels appear to be a suitable biomonitor for exposure to hydroxyethylating agents in cigarette smoke, reflecting an integrated dose over the erythrocyte lifetime, in contrast to plasma cotinine determinations which reflect only the previous day's exposure to nicotine in smoke.
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•Journal Article
Methylation of cysteine in hemoglobin following exposure to methylating agents.
TL;DR: The degree of S-methylation of cysteine in hemoglobin was studied following in vivo exposure of rats to methyl methanesulfonate, dimethylnitrosamine, and 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide; however, the existence of naturally occurring S- methylcysteines in the rat hemoglobin may have overshadowed small increases in alkylation arising from exposure to this compound.
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Estimation of exposure to alkylating carcinogens by the GC-MS determination of adducts to hemoglobin and nucleic acid bases in urine.
TL;DR: Methods have been developed using capillary gas chromatography with mass spectrometry for determining S-methylcysteine, Nr-[2-hydroxyethyl]histidine and Nr]-2-Hydroxypropyl] histidine in hemoglobin, allowing the monitoring of in vivo exposure of laboratory animals and humans to methylating agents, ethylene oxide and propylene oxide, respectively.
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Reduction of nitromin to nitrogen mustard: unscheduled DNA synthesis in aerobic or anaerobic rat hepatocytes, JB1, BL8 and Walker carcinoma cell lines.
Ian N.H. White,Mohammad Suzanger,A. Robin Mattocks,Eric Bailey,Peter B. Farmer,Thomas A. Connors +5 more
TL;DR: A novel route for the microsomal generation of nitrogen mustard from its N-oxide nitromin is demonstrated and greater induction of UDS occurred in cells incubated with Nitromin under anaerobic conditions.
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The determination of urinary 3-methyladenine in humans as a potential monitor of exposure to methylating agents
TL;DR: The determination of urinary 3-methyladenine has been explored as a potential monitor of exposure to methylating carcinogens and a method based on the use of high resolution gas chromatography--mass spectrometry has been developed for measuring this methylated base in human urine.
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