Eric B. Bell
University of Manchester
68 Papers
734 Citations
Eric B. Bell is an academic researcher from University of Manchester. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 24, co-authored 68 publications. Previous affiliations of Eric B. Bell include University of Santiago de Compostela.
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Papers
CD4+ T-cell memory, CD45R subsets and the persistence of antigen—a unifying concept
TL;DR: It is argued that two crucial components of memory—rapid recall and long life—belong not to one but to two distinct subsets of CD4 + memory T cells: the CD45R lo andCD45R hi subsets, respectively.
209
•Journal Article
The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.
TL;DR: DTL-injected nude rats rejected skin allografts with near normal kinetics and graft vs host (GVH) responsiveness, assessed by the popliteal LN assay, progressively increased reaching a level 9 mo to 1 yr after replacement that resembled the GVH activity in euthymic controls.
177
Cd45rc isoforms define two types of cd4 memory t cells, one of which depends on persisting antigen
Campbell Bunce,Eric B. Bell +1 more
TL;DR: The results indicate that there are two functionally distinct categories of memory T cells: one, a short-lived CD45Rlow type which orchestrates the rapid kinetics, the other, a longer-livedCD45Rhigh revertant which ensures that immunological memory endures.
135
Functional maturation of recent thymic emigrants in the periphery: development of alloreactivity correlates with the cyclic expression of CD45RC isoforms.
Chun-Ping Yang,Eric B. Bell +1 more
TL;DR: The transition of SP (CD45RC−) thymocytes to fully mature CD45RC+ CD4 T cells via intermediate peripheral RTE was accompanied at each stage by an increased ability of the maturing T cells to induce skin allograft rejection, and the subsequent loss of the high molecular weight isoform was associated with a significant reduction in the ability of this Thy‐1− CD 45RC− subpopulation to effect graft rejection.
69
CD4+ T cell-mediated rejection of major histocompatibility complex class I-disparate grafts: a role for alloantibody"
A. Lawrie Morton,Eric B. Bell,Eleanor M. Bolton,H. E. Marshall,Chris Roadknight,Mark McDonagh,J. Andrew Bradley +6 more
TL;DR: It is demonstrated that CD4+ T cells are both necessary and sufficient to cause rejection of class I‐disparate heart and skin grafts in this model and that CD 4+ T cell‐dependent alloantibody plays a decisive role in effecting rejection.
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