Eric Austin
NHS Blood and Transplant
10 Papers
34 Citations
Eric Austin is an academic researcher from NHS Blood and Transplant. The author has contributed to research in topics: Mesenchymal stem cell & Medicine. The author has an hindex of 7, co-authored 10 publications. Previous affiliations of Eric Austin include National Blood Service & National Health Service.
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Papers
The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity.
Fiona C Thistlethwaite,Fiona C Thistlethwaite,David E. Gilham,Ryan D. Guest,Dominic G. Rothwell,Manon Pillai,Manon Pillai,Deborah J. Burt,Andrea J. Byatte,Natalia Kirillova,Juan W. Valle,Juan W. Valle,Surinder K. Sharma,Kerry A. Chester,Nigel B. Westwood,Sarah E. R. Halford,Stephen Nabarro,Susan Wan,Eric Austin,Robert E. Hawkins,Robert E. Hawkins +20 more
TL;DR: Improved CAR designs and T cell production methods could improve the systemic persistence and activity, methods to control CAR T ‘on-target, off-tissue’ toxicity are required to enable a clinical impact of this approach in solid malignancies.
Repair of Torn Avascular Meniscal Cartilage Using Undifferentiated Autologous Mesenchymal Stem Cells: From In Vitro Optimization to a First-in-Human Study.
Michael R Whitehouse,N. R. Howells,Michael Parry,Eric Austin,Wael Kafienah,Kyla Brady,Allen E. Goodship,Jonathan Eldridge,Ashley W Blom,Anthony P. Hollander +9 more
TL;DR: Undifferentiated autologous mesenchymal stem cells could provide a safe way to augment avascular meniscal repair in some patients, and this method into a cell therapy for patients with torn meniscus is translated.
Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration
Lauren Scarfe,Arthur Taylor,Jack Sharkey,Rachel Harwood,Michael Barrow,Joan Comenge,Lydia Beeken,Cai Astley,Ilaria Santeramo,Claire Hutchinson,Lorenzo Ressel,Jon Smythe,Eric Austin,Raphaël Lévy,Matthew J. Rosseinsky,Dave J. Adams,Harish Poptani,Brian Kevin Park,Patricia Murray,Bettina Wilm +19 more
TL;DR: The observation that the hUC-MSCs but not the human bone marrow (hBM)-derived MSCs persisted for a period in some animals suggests that therapies with these cells should proceed with caution, and a thorough understanding of cell biodistribution and fate post administration is required.
Cryopreservation of hematopoietic stem/progenitor cells for therapeutic use.
TL;DR: Several protocols that are used to cryopreserve different sources of hematopoietic stem/progenitor cells are described, keeping in mind that the protocols may vary among transplant processing centers.
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Adoptive transfer of T(reg) depleted autologous T cells in advanced renal cell carcinoma.
Fiona C Thistlethwaite,Eyad Elkord,Richard Griffiths,Deborah J. Burt,Alaaeldin Shablak,John D. M. Campbell,David E. Gilham,Eric Austin,Peter L. Stern,Robert E. Hawkins +9 more
TL;DR: The results provide proof of concept in potentiation of tumour antigen T cell responses when Treg cell levels are depleted, and a need to explore further strategies to improve the safety and efficacy of this approach.
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