Eric A. Jaffe
State University of New York System
2 Papers
297 Citations
Eric A. Jaffe is an academic researcher from State University of New York System. The author has contributed to research in topics: Vascular endothelial growth factor A & Kinase insert domain receptor. The author has an hindex of 2, co-authored 2 publications.
Chat about Author
Papers
Utilization of Distinct Signaling Pathways by Receptors for Vascular Endothelial Cell Growth Factor and Other Mitogens in the Induction of Endothelial Cell Proliferation
Li Wha Wu,Lindsey D. Mayo,James D. Dunbar,Kelly M. Kessler,Melinda R. Baerwald,Eric A. Jaffe,Dongfang Wang,Robert S. Warren,David B. Donner +8 more
TL;DR: Two-hybrid cloning and immunoprecipitation from human umbilical vein endothelial cells (HUVEC) showed that KDR binds to and promotes the tyrosine phosphorylation of phospholipase Cγ (PLCγ), indicating that K DR is uniquely important to PLCγ activation in HUVEC.
301
Tumor Necrosis Factor Employs a Protein-tyrosine Phosphatase to Inhibit Activation of KDR and Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation
Dan Qun Guo,Li Wha Wu,James D. Dunbar,Osman N. Ozes,Lindsey D. Mayo,Kelly M. Kessler,Jason A. Gustin,Melinda R. Baerwald,Eric A. Jaffe,Robert S. Warren,David B. Donner +10 more
TL;DR: Heterologous receptor inactivation mediated by a protein-tyrosine phosphatase provides insight into how TNF may inhibit endothelial cell proliferative responses and modulate angiogenesis in pathological settings.