Eri Nobusawa
National Institutes of Health
18 Papers
144 Citations
Eri Nobusawa is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 10, co-authored 18 publications.
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Papers
The Host Protease TMPRSS2 Plays a Major Role in In Vivo Replication of Emerging H7N9 and Seasonal Influenza Viruses
Kouji Sakai,Yasushi Ami,Maino Tahara,Toru Kubota,Masaki Anraku,Masako Abe,Noriko Nakajima,Tsuyoshi Sekizuka,Kazuya Shirato,Yuriko Suzaki,Akira Ainai,Yuichiro Nakatsu,Kazuhiko Kanou,Kazuya Nakamura,Tadaki Suzuki,Katsuhiro Komase,Eri Nobusawa,Katsumi Maenaka,Makoto Kuroda,Hideki Hasegawa,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Masato Tashiro,Makoto Takeda +23 more
TL;DR: The results demonstrate that recently emerged H7N9 as well as seasonal IAVs mainly use the specific protease TMPRSS2 for HA cleavage in vivo and, thus, that TMPR SS2 expression is essential for IAV replication in vivo.
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Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
Stacey Schultz-Cherry,Richard J. Webby,Robert G. Webster,Anne Kelso,Ian G. Barr,John W. McCauley,Rod S. Daniels,Dayan Wang,Yuelong Shu,Eri Nobusawa,Shigeyuki Itamura,Masato Tashiro,Yuichi Harada,Shinji Watanabe,Takato Odagiri,Zhiping Ye,Gary Grohmann,Ruth Harvey,Othmar G. Engelhardt,Derek J. Smith,K. Hamilton,Filip Claes,Gwenaelle Dauphin +22 more
TL;DR: Specific examples are provided of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community.
29
Genetics and infectivity of H5N1 highly pathogenic avian influenza viruses isolated from chickens and wild birds in Japan during 2010–11
Yuko Uchida,Yasushi Suzuki,Masayuki Shirakura,Akira Kawaguchi,Eri Nobusawa,Taichiro Tanikawa,Hirokazu Hikono,Nobuhiro Takemae,Masaji Mase,Katsushi Kanehira,Tsuyoshi Hayashi,Yuichi Tagawa,Masato Tashiro,Takehiko Saito +13 more
TL;DR: Outbreaks of H5N1 subtype highly pathogenic avian influenza virus (HPAIV) were recorded in chickens, domesticated birds and wild birds throughout Japan from November 2010 to March 2011, and reduced virus excretion and transmission of MandarinD11 could have been due to adaptation of the virus in wild birds.
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Prediction of probable mutations in influenza virus hemagglutinin protein based on large-scale ab initio fragment molecular orbital calculations
Akio Yoshioka,Kaori Fukuzawa,Yuji Mochizuki,Katsumi Yamashita,Tatsuya Nakano,Yoshio Okiyama,Eri Nobusawa,Katsuhisa Nakajima,Shigenori Tanaka +8 more
TL;DR: The proposed protocol based on the FMO-MP2.5 calculation can explain the historical facts concerning the actual mutations after the emergence of A/Hong Kong/1/68 influenza virus with subtype H3N2, and thus provides a useful methodology to enumerate those residue sites likely to mutate in the future.
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Generation of a Genetically Stable High-Fidelity Influenza Vaccine Strain
Tadasuke Naito,Kotaro Mori,Kotaro Mori,Hiroshi Ushirogawa,Naoki Takizawa,Eri Nobusawa,Takato Odagiri,Masato Tashiro,Ryosuke L. Ohniwa,Ryosuke L. Ohniwa,Kyosuke Nagata,Mineki Saito +11 more
TL;DR: This study shows that the mutant PR8 virus possessing the PB1 polymerase with the V43I substitution may be utilized as a master virus for the generation of high-growth vaccine viruses with high polymerase fidelity, low error rates of gene replication, and reduced antigenic diversity during virus propagation in eggs for vaccine production.
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