Er Yun Chen
Rush University Medical Center
10 Papers
43 Citations
Er Yun Chen is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Striatum & Internal medicine. The author has an hindex of 9, co-authored 10 publications.
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Papers
Functional fetal nigral grafts in a patient with Parkinson's disease: Chemoanatomic, ultrastructural, and metabolic studies
Jeffrey H. Kordower,Jeffrey M. Rosenstein,Timothy J. Collier,Melanie A. Burke,Er Yun Chen,Jing Min Li,Leena Martel,Allan E. Levey,Elliott J. Mufson,Thomas B. Freeman,C. Warren Olanow +10 more
TL;DR: Fetal nigral neurons can survive transplantation, functionally reinnervate the host putamen, establish synaptic contacts with host neurons, and sustain many of the morphological and functional characteristics of normal Nigral neurons following grafting into a patient with PD.
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Human neural stem cell transplants improve motor function in a rat model of Huntington's disease.
Jodi L. McBride,Soshana Behrstock,Er Yun Chen,Rebekah J. Jakel,Irwin M. Siegel,Clive N. Svendsen,Jeffrey H. Kordower +6 more
TL;DR: Data demonstrate that striatal transplants of human fetal stem cells elicit behavioral and anatomical recovery in a rodent model of Huntington's disease.
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B2 bradykinin receptor immunoreactivity in rat brain.
TL;DR: The widespread distribution of bradykinin B2 receptor immunoreactivity in neuronal compartments suggests a greater than previously appreciated role for this peptide in neuronal function.
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Nigrostriatal Dysfunction in Familial Alzheimer's Disease-Linked APPswe/PS1ΔE9 Transgenic Mice
Sylvia E. Perez,Orly Lazarov,James B. Koprich,Er Yun Chen,Virginia Rodriguez-Menendez,Jack W. Lipton,Sangram S. Sisodia,Elliott J. Mufson +7 more
TL;DR: It is shown that Aβ deposition is pronounced in the striatum of APPswe/PS1ΔE9 mice at 6 months of age, and the extent of deposition increases in an age-dependent manner, and altered FAD-linked amyloid metabolism impairs the function of dopaminergic neurons.
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Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) alters exploratory behavior, reduces monoamine metabolism, and increases forebrain tyrosine hydroxylase fiber density of juvenile rats.
James B. Koprich,Er Yun Chen,Nicholas M. Kanaan,Nicholas G. Campbell,Jeffrey H. Kordower,Jack W. Lipton +5 more
TL;DR: Findings provide the first evidence of lasting neurochemical and behavioral alterations following prenatal MDMA, and are warranted to elucidate possible mechanisms of action and to monitor children gestationally exposed to MDMA.
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