En Li
Novartis
7 Papers
30 Citations
En Li is an academic researcher from Novartis. The author has contributed to research in topics: DNA methylation & RNA-Directed DNA Methylation. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of En Li include Harvard University.
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Papers
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin
Bernhard Lehnertz,Yoshihide Ueda,Alwin A.H.A. Derijck,Ulrich Braunschweig,Laura Perez-Burgos,Stefan Kubicek,Taiping Chen,En Li,Thomas Jenuwein,Antoine H.F.M. Peters +9 more
TL;DR: An evolutionarily conserved pathway between histone H3-K9 methylation and DNA methylation in mammals is demonstrated and both methylation systems are likely to be important in reinforcing the stability of heterochromatic subdomains and thereby in protecting genome integrity.
1.3K
Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.
TL;DR: It is demonstrated that genomic methylation patterns are determined partly through differential expression of different Dnmt3a and DNmt3b isoforms, and that hypermethylation of genomic DNA by Dn MT3b is necessary for ES cells to form teratomas in nude mice.
796
A methyl-CpG-binding protein 2-enhanced green fluorescent protein reporter mouse model provides a new tool for studying the neuronal basis of Rett syndrome.
TL;DR: This work generates a knock-in reporter mouse model that expresses MeCP2–enhanced green fluorescent protein (EGFP) fusion protein instead of endogenous Me CP2 and shows that expression of the fusion protein in the brain remarkably mirrors endogenous MeCP 2 expression in all temporal and spatial aspects.
26
Defective heart development in hypomorphic LSD1 mice.
Thomas B. Nicholson,Hui Su,Sarah Hevi,Jing Wang,Jeff Bajko,Mei Li,Reginald Valdez,Joseph Loureiro,Xiaodong Cheng,En Li,Bernd Kinzel,Mark Labow,Taiping Chen +12 more
TL;DR: A hypomorphic LSD1 allele that contains two point mutations in the tower domain is described, resulting in a protein with reduced interaction with known binding partners and decreased enzymatic activity, identifying a previously unknown role for LSD1 in heart development.
A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.
TL;DR: Comparison of human embryonal carcinoma cell lines with breast/ovarian cancer cell lines indicates that DNMT3A2 expression correlates with high de novo methylation activity, suggesting that Dnmt3a and DnMT3a2 may have distinct DNA targets and different functions in development.