Emmanuel Delay
University of Lyon
7 Papers
19 Citations
Emmanuel Delay is an academic researcher from University of Lyon. The author has contributed to research in topics: Stem cell & Progenitor cell. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Emmanuel Delay include French Institute of Health and Medical Research.
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Papers
Disequilibrium of BMP2 levels in the breast stem cell niche launches epithelial transformation by overamplifying BMPR1B cell response.
Marion Chapellier,Elodie Bachelard-Cascales,Xenia Schmidt,Flora Clément,Isabelle Treilleux,Emmanuel Delay,Alexandre Jammot,Christine Ménétrier-Caux,Gaëtan Pochon,Roger Besançon,Thibault Voeltzel,Claude Caron de Fromentel,Christophe Caux,Jean-Yves Blay,Richard Iggo,Véronique Maguer-Satta +15 more
TL;DR: A role for BMP2 and the breast microenvironment in the initiation of stem cell transformation is revealed, thus providing insight into the etiology of luminal breast cancer.
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CD10: A tool to crack the role of stem cells in breast cancer
TL;DR: This work has demonstrated the key role of CD10 not only as a cell surface marker but as a full functional regulator of normal mammary progenitor cells and indicates that a gradient of biological peptides generated by CD10-enzyme cleavage is involved in maintaining stem cells/early progenitors and regulating their conversion to luminal progensitors.
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A Protocol to Quantify Mammary Early Common Progenitors from Long‐Term Mammosphere Culture
Elodie Bachelard-Cascales,Marion Chapellier,Emmanuel Delay,Emmanuel Delay,Véronique Maguer-Satta +4 more
TL;DR: This protocol is based on the combination of two functional tests: the mammosphere assay to maintain and enrich early mammary progenitor/stem cells, and the epithelial colony-forming cells (E-CFC) assay to identify and quantify further differentiated epithelial progenitors.
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Quantifying Epithelial Early Common Progenitors from Long-Term Primary or Cell Line Sphere Culture.
Flora Clément,Flora Clément,Flora Clément,Helen He Zhu,Wei-Qiang Gao,Emmanuel Delay,Véronique Maguer-Satta +6 more
TL;DR: This protocol is based on the combination of two functional tests: the sphere assay to maintain and enrich early progenitor/stem cells, and the epithelial colony-forming cells (E-CFC) assay to identify and quantify further differentiated epithelial progenitors.
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Long-term exposure to bisphenol A or benzo(a)pyrene alters the fate of human mammary epithelial stem cells in response to BMP2 and BMP4, by pre-activating BMP signaling.
Flora Clément,Xinyi Xu,Caterina F Donini,Alice Clement,Soleilmane Omarjee,Emmanuel Delay,Isabelle Treilleux,Béatrice Fervers,Muriel Le Romancer,Pascale A. Cohen,Véronique Maguer-Satta +10 more
TL;DR: It is demonstrated that chronic exposure to low doses of bisphenol A or benzo( a)pyrene (B(a)P) alone has little effect on SCs properties of MCF10A cells, and that BPA prevents the maintenance of SC features prompted by BMP4, whereas promoting cell differentiation towards a myoepithelial phenotype is prevented.