Emmanuel Datan
City University of New York
14 Papers
Emmanuel Datan is an academic researcher from City University of New York. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Emmanuel Datan include Johns Hopkins University.
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Papers
Flavivirus NS4A-induced Autophagy Protects Cells against Death and Enhances Virus Replication
TL;DR: It is reported that, in epithelial cells, up-regulation of autophagy following flavivirus infection markedly enhances virus replication and that one flaviv virus gene, NS4A, uniquely determines the up- regulation of Autophagy.
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Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation
Emmanuel Datan,Sounak Ghosh Roy,Gabrielle Germain,N Zali,Jeffrey E. McLean,G Golshan,S Harbajan,Richard A. Lockshin,Zahra Zakeri +8 more
TL;DR: It is demonstrated that among the multiple autophagy-inducing pathways during infection, ER stress signaling is more important to viral replication and protection of cells than either ATM or ROS-mediated signaling.
Triptolide: reflections on two decades of research and prospects for the future.
Lu Tong,Qunfei Zhao,Emmanuel Datan,Guo Qiang Lin,Il Minn,Martin G. Pomper,Biao Yu,Daniel Romo,Qing-Li He,Jun O. Liu +9 more
TL;DR: This review highlights advances in material sourcing, molecular mechanisms, clinical progress and new drug design strategies for triptolide over the past two decades, along with some prospects for the future course of development.
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Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation.
Qing-Li He,Il Minn,Qiaoling Wang,Peng Xu,Sarah A. Head,Emmanuel Datan,Biao Yu,Martin G. Pomper,Jun O. Liu +8 more
TL;DR: Glutriptolide did not inhibit XPB activity in vitro but demonstrated significantly higher cytotoxicity against tumor cells over normal cells with greater water solubility than triptolide, indicating that glutriptolides may serve as a promising lead for developing a new mechanistic class of anticancer drugs.
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mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection
Emmanuel Datan,Alireza Shirazian,Shawna Benjamin,Demetrius Matassov,Antonella Tinari,Walter Malorni,Richard A. Lockshin,Adolfo García-Sastre,Zahra Zakeri +8 more
TL;DR: Expanded, lethal autophagy is activated by a signaling mechanism different from autophophagy that helps cells survive toxic or stressful episodes that limit virus reproduction.
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