Emmanouil Tsafantakis
42 Papers
525 Citations
Emmanouil Tsafantakis is an academic researcher. The author has contributed to research in topics: Population & Biology. The author has an hindex of 14, co-authored 32 publications.
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Papers
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Thomas W. Winkler,Anne E. Justice,Mariaelisa Graff,Llilda Barata,Mary F. Feitosa,Su H. Chu,Jacek Czajkowski,Tõnu Esko,Tove Fall,Tuomas O. Kilpeläinen,Yingchang Lu,Reedik Mägi,Evelin Mihailov,Tune H. Pers,Sina Rüeger,Alexander Teumer,Georg Ehret,Teresa Ferreira,Nancy L. Heard-Costa,Juha Karjalainen,Vasiliki Lagou,Anubha Mahajan,Michael D. Neinast,Inga Prokopenko,Jeannette Simino,Tanya M. Teslovich,Rick Jansen,Harm-Jan Westra,Charles C. White,Devin Absher,Tarunveer S. Ahluwalia,Shafqat Ahmad,Eva Albrecht,Alexessander Couto Alves,Jennifer L. Bragg-Gresham,Anton J. M. de Craen,Joshua C. Bis,Amélie Bonnefond,Gabrielle Boucher,Gemma Cadby,Yu-Ching Cheng,Charleston W. K. Chiang,Graciela Delgado,Ayse Demirkan,Nicole Dueker,Niina Eklund,Gudny Eiriksdottir,Joel Eriksson,Bjarke Feenstra,Krista Fischer,Francesca Frau,Tessel E. Galesloot,Frank Geller,Anuj Goel,Mathias Gorski,Tanja B. Grammer,Stefan Gustafsson,Saskia Haitjema,Jouke-Jan Hottenga,Jennifer E. Huffman,Anne U. Jackson,Kevin B. Jacobs,Åsa Johansson,Marika Kaakinen,Marcus E. Kleber,Jari Lahti,Irene Mateo Leach,Benjamin Lehne,Youfang Liu,Ken Sin Lo,Mattias Lorentzon,Jian'an Luan,Pamela A. F. Madden,Massimo Mangino,Barbara McKnight,Carolina Medina-Gomez,Keri L. Monda,May E. Montasser,Gabriele Müller,Martina Müller-Nurasyid,Ilja M. Nolte,Kalliope Panoutsopoulou,Laura Pascoe,Lavinia Paternoster,Nigel W. Rayner,Frida Renström,Federica Rizzi,Lynda M. Rose,Kathy Ryan,Perttu Salo,Serena Sanna,Hubert Scharnagl,Jianxin Shi,Albert V. Smith,Lorraine Southam,Alena Stančáková,Valgerdur Steinthorsdottir,Rona J. Strawbridge,Yun Ju Sung,Ioanna Tachmazidou,Toshiko Tanaka,Gudmar Thorleifsson,Stella Trompet,Natalia Pervjakova,Jonathan Tyrer,Liesbeth Vandenput,Sander W. van der Laan,Nathalie van der Velde,Jessica van Setten,Jana V. van Vliet-Ostaptchouk,Niek Verweij,Efthymia Vlachopoulou,Lindsay L. Waite,Sophie R. Wang,Zhaoming Wang,Sarah H. Wild,Christina Willenborg,James F. Wilson,Andrew Wong,Jian Yang,Loic Yengo,Laura M. Yerges-Armstrong,Lei Yu,Weihua Zhang,Jing Hua Zhao,Ehm A. Andersson,Stephan J. L. Bakker,Damiano Baldassarre,Karina Banasik,Matteo Barcella,Cristina Barlassina,Claire Bellis,Paola Benaglio,John Blangero,Matthias Blüher,Fabrice Bonnet,Lori L. Bonnycastle,Heather A. Boyd,Marcel Bruinenberg,Aron S. Buchman,Harry Campbell,Yii-Der Ida Chen,Peter S. Chines,Simone Claudi-Boehm,John B. Cole,Francis S. Collins,Eco J. C. de Geus,Lisette C. P. G. M. de Groot,Maria Dimitriou,Jubao Duan,Stefan Enroth,Elodie Eury,Aliki-Eleni Farmaki,Nita G. Forouhi,Nele Friedrich,Pablo V. Gejman,Bruna Gigante,Nicola Glorioso,Alan S. Go,Omri Gottesman,Jürgen Gräßler,Harald Grallert,Niels Grarup,Yu Mei Gu,Linda Broer,Annelies C. Ham,Torben Hansen,Tamara B. Harris,Catharina A. Hartman,Maija Hassinen,Nicholas D. Hastie,Andrew T. Hattersley,Andrew C. Heath,Anjali K. Henders,Dena G. Hernandez,Hans L. Hillege,Oddgeir L. Holmen,Kees Hovingh,Jennie Hui,Lise Lotte N. Husemoen,Nina Hutri-Kähönen,Pirro G. Hysi,Thomas Illig,Philip L. De Jager,Shapour Jalilzadeh,Torben Jørgensen,J. Wouter Jukema,Markus Juonala,Stavroula Kanoni,Maria Karaleftheri,Kay-Tee Khaw,Leena Kinnunen,Steven J. Kittner,Wolfgang Koenig,Ivana Kolcic,Peter Kovacs,Nikolaj T. Krarup,Wolfgang Kratzer,Janine Krüger,Diana Kuh,Meena Kumari,Theodosios Kyriakou,Claudia Langenberg,Lars Lannfelt,Chiara Lanzani,Vaneet Lotay,Lenore J. Launer,Karin Leander,Jaana Lindström,Allan Linneberg,Yan Ping Liu,Stéphane Lobbens,Robert Luben,Valeriya Lyssenko,Satu Männistö,Patrik K. E. Magnusson,Wendy L. McArdle,Cristina Menni,Sigrun Merger,Lili Milani,Grant W. Montgomery,Andrew P. Morris,Narisu Narisu,Mari Nelis,Ken K. Ong,Aarno Palotie,Louis Pérusse,Irene Pichler,Maria Grazia Pilia,Anneli Pouta,Myriam Rheinberger,Rasmus Ribel-Madsen,Marcus Richards,Kenneth Rice,Treva Rice,Carlo Rivolta,Veikko Salomaa,Alan R. Sanders,Mark A. Sarzynski,Salome Scholtens,Robert A. Scott,William R. Scott,Sylvain Sebert,Sebanti Sengupta,Bengt Sennblad,Thomas Seufferlein,Angela Silveira,P. Eline Slagboom,Jan Smit,Thomas Sparsø,Kathleen Stirrups,Ronald P. Stolk,Heather M. Stringham,Morris A. Swertz,Amy J. Swift,Ann-Christine Syvänen,Sian Tsung Tan,Barbara Thorand,Anke Tönjes,Angelo Tremblay,Emmanouil Tsafantakis,Peter J. van der Most,Uwe Völker,Marie-Claude Vohl,Judith M. Vonk,Melanie Waldenberger,Ryan W. Walker,Roman Wennauer,Elisabeth Widen,Gonneke Willemsen,Tom Wilsgaard,Alan F. Wright,M. Carola Zillikens,Suzanne C. van Dijk,Natasja M. van Schoor,Folkert W. Asselbergs,Paul I.W. de Bakker,Jacques S. Beckmann,John Beilby,David A. Bennett,Richard N. Bergman,Sven Bergmann,Carsten A. Böger,Bernhard O. Boehm,Eric Boerwinkle,Dorret I. Boomsma,Stefan R. Bornstein,Erwin P. Bottinger,Claude Bouchard,John C. Chambers,Stephen J. Chanock,Daniel I. Chasman,Francesco Cucca,Daniele Cusi,George Dedoussis,Jeanette Erdmann,Johan G. Eriksson,Denis A. Evans,Ulf de Faire,Martin Farrall,Luigi Ferrucci,Ian Ford,Lude Franke,Paul W. Franks,Philippe Froguel,Ron T. Gansevoort,Christian Gieger,Henrik Grönberg,Vilmundur Gudnason,Ulf Gyllensten,Per Hall,Anders Hamsten,Pim van der Harst,Caroline Hayward,Markku Heliövaara,Christian Hengstenberg,Andrew A. Hicks,Aroon D. Hingorani,Albert Hofman,Frank B. Hu,Heikki V. Huikuri,Kristian Hveem,Alan L. James,Joanne M. Jordan,Antti Jula,Mika Kähönen,Eero Kajantie,Sekar Kathiresan,Lambertus A. Kiemeney,Mika Kivimäki,Paul Knekt,Heikki A. Koistinen,Jaspal S. Kooner,Seppo Koskinen,Johanna Kuusisto,Winfried Maerz,Nicholas G. Martin,Markku Laakso,Timo A. Lakka,Terho Lehtimäki,Guillaume Lettre,Douglas F. Levinson,Lars Lind,Marja-Liisa Lokki,Pekka Mäntyselkä,Mads Melbye,Andres Metspalu,Braxton D. Mitchell,Frans L. Moll,Jeffrey C. Murray,Arthur W. Musk,Markku S. Nieminen,Inger Njølstad,Claes Ohlsson,Albertine J. Oldehinkel,Ben A. Oostra,Lyle J. Palmer,James S. Pankow,Gerard Pasterkamp,Nancy L. Pedersen,Oluf Pedersen,Brenda W.J.H. Penninx,Markus Perola,Annette Peters,Ozren Polasek,Peter P. Pramstaller,Bruce M. Psaty,Lu Qi,Thomas Quertermous,Olli T. Raitakari,Tuomo Rankinen,Rainer Rauramaa,Paul M. Ridker,John D. Rioux,Fernando Rivadeneira,Jerome I. Rotter,Igor Rudan,Hester M. den Ruijter,Juha Saltevo,Naveed Sattar,Heribert Schunkert,Peter Schwarz,Alan R. Shuldiner,Juha Sinisalo,Harold Snieder,Thorkild I. A. Sørensen,Tim D. Spector,Jan A. Staessen,Bandinelli Stefania,Unnur Thorsteinsdottir,Michael Stumvoll,Jean-Claude Tardif,Elena Tremoli,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,André L. M. Verbeek,Sita H. Vermeulen,Jorma Viikari,Veronique Vitart,Henry Völzke,Peter Vollenweider,Gérard Waeber,Mark Walker,Henri Wallaschofski,Nicholas J. Wareham,Hugh Watkins,Eleftheria Zeggini,Aravinda Chakravarti,Deborah J. Clegg,L. Adrienne Cupples,Penny Gordon-Larsen,Cashell E. Jaquish,Dabeeru C. Rao,Gonçalo R. Abecasis,Themistocles L. Assimes,Inês Barroso,Sonja I. Berndt,Michael Boehnke,Panos Deloukas,Caroline S. Fox,Leif Groop,David J. Hunter,Erik Ingelsson,Robert C. Kaplan,Mark I. McCarthy,Karen L. Mohlke,Jeffrey R. O'Connell,David Schlessinger,David P. Strachan,Kari Stefansson,Cornelia M. van Duijn,Joel N. Hirschhorn,Cecilia M. Lindgren,Iris M. Heid,Kari E. North,Ingrid B. Borecki,Zoltán Kutalik,Ruth J. F. Loos +438 more
TL;DR: In this paper, the authors performed meta-analyses of 114 studies with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium.
Rare and low-frequency coding variants alter human adult height
Eirini Marouli,Mariaelisa Graff,Carolina Medina-Gomez,Ken Sin Lo,Andrew R. Wood,Troels R. Kjaer,Rebecca S. Fine,Yingchang Lu,Claudia Schurmann,Heather M. Highland,Sina Rüeger,Gudmar Thorleifsson,Anne E. Justice,David Lamparter,Kathleen Stirrups,Valérie Turcot,Kristin L. Young,Thomas W. Winkler,Tõnu Esko,Tugce Karaderi,Adam E. Locke,Nicholas G. D. Masca,Maggie C.Y. Ng,Poorva Mudgal,Manuel A. Rivas,Sailaja Vedantam,Anubha Mahajan,Xiuqing Guo,Gonçalo R. Abecasis,Katja K.H. Aben,Linda S. Adair,Dewan S. Alam,Eva Albrecht,Kristine H. Allin,Matthew A. Allison,Philippe Amouyel,Emil V. R. Appel,Dominique Arveiler,Folkert W. Asselbergs,Paul L. Auer,Beverley Balkau,Bernhard Banas,Lia E. Bang,Marianne Benn,Sven Bergmann,Lawrence F. Bielak,Matthias Blueher,Heiner Boeing,Eric Boerwinkle,Carsten A. Boeger,Lori L. Bonnycastle,Jette Bork-Jensen,Michiel L. Bots,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Gerome Breen,Murray H. Brilliant,Linda Broer,Amber A. Burt,Adam S. Butterworth,David J. Carey,Mark J. Caulfield,John C. Chambers,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Massimiliano Cocca,Francis S. Collins,James P. Cook,Janie Corley,Jordi Corominas Galbany,Amanda J. Cox,Gabriel Cuellar-Partida,John Danesh,Gail Davies,Paul I.W. de Bakker,Gert J. de Borst,Simon de Denus,Mark C.H. De Groot,Renée de Mutsert,Ian J. Deary,George Dedoussis,Ellen W. Demerath,Anneke I. den Hollander,Joe Dennis,Emanuele Di Angelantonio,Fotios Drenos,Mengmeng Du,Alison M. Dunning,Douglas F. Easton,Tapani Ebeling,Todd L. Edwards,Patrick T. Ellinor,Paul Elliott,Evangelos Evangelou,Aliki-Eleni Farmaki,Jessica D. Faul,Mary F. Feitosa,Shuang Feng,Ele Ferrannini,Marco M Ferrario,Jean Ferrières,Jose C. Florez,Ian Ford,Myriam Fornage,Paul W. Franks,Ruth Frikke-Schmidt,Tessel E. Galesloot,Wei Gan,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Ayush Giri,Giorgia Girotto,Scott D. Gordon,Penny Gordon-Larsen,Mathias Gorski,Niels Grarup,Megan L. Grove,Vilmundur Gudnason,Stefan Gustafsson,Torben Hansen,Kathleen Mullan Harris,Tamara B. Harris,Andrew T. Hattersley,Caroline Hayward,Liang He,Iris M. Heid,Kauko Heikkilä,Øyvind Helgeland,Jussi Hernesniemi,Alex W. Hewitt,Lynne J. Hocking,Mette Hollensted,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Carel B. Hoyng,Paul L. Huang,Kristian Hveem,M. Arfan Ikram,Erik Ingelsson,Anne U. Jackson,Jan-Håkan Jansson,Gail P. Jarvik,Gorm B. Jensen,Min A. Jhun,Yucheng Jia,Xuejuan Jiang,Stefan Johansson,Marit E. Jørgensen,Torben Jørgensen,Pekka Jousilahti,J. Wouter Jukema,Bratati Kahali,René S. Kahn,Mika Kähönen,Pia R. Kamstrup,Stavroula Kanoni,Jaakko Kaprio,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Frank Kee,Renske Keeman,Lambertus A. Kiemeney,Hidetoshi Kitajima,Kirsten B. Kluivers,Thomas D. Kocher,Pirjo Komulainen,Jukka Kontto,Jaspal S. Kooner,Charles Kooperberg,Peter Kovacs,Jennifer Kriebel,Helena Kuivaniemi,Sébastien Küry,Johanna Kuusisto,Martina La Bianca,Markku Laakso,Timo A. Lakka,Ethan M. Lange,Leslie A. Lange,Carl D. Langefeld,Claudia Langenberg,Eric B. Larson,I-Te Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Honghuang Lin,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Y Liu,Yongmei Liu,Artitaya Lophatananon,Jian'an Luan,Steven A. Lubitz,Leo-Pekka Lyytikäinen,David A. Mackey,Pamela A. F. Madden,Alisa K. Manning,Satu Männistö,Gaëlle Marenne,Jonathan Marten,Nicholas G. Martin,Angela L. Mazul,Karina Meidtner,Andres Metspalu,Paul Mitchell,Karen L. Mohlke,Dennis O. Mook-Kanamori,Anna Morgan,Andrew D. Morris,Andrew P. Morris,Martina Mueller-Nurasyid,Patricia B. Munroe,Mike A. Nalls,Matthias Nauck,Christopher P. Nelson,Matt Neville,Sune F. Nielsen,Kjell Nikus,Pål R. Njølstad,Børge G. Nordestgaard,Ioanna Ntalla,Jeffrey R. O'Connel,Heikki Oksa,Loes M. Olde Loohuis,Roel A. Ophoff,Katharine R. Owen,Chris J. Packard,Sandosh Padmanabhan,Colin N. A. Palmer,Gerard Pasterkamp,Aniruddh P. Patel,Alison Pattie,Oluf Pedersen,Peggy L. Peissig,Gina M. Peloso,Craig E. Pennell,Markus Perola,James A. Perry,John R. B. Perry,Thomas N. Person,Ailith Pirie,Ozren Polasek,Danielle Posthuma,Olli T. Raitakari,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Alexander P. Reiner,Frida Renström,Paul M. Ridker,John D. Rioux,Neil Robertson,Antonietta Robino,Olov Rolandsson,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Kevin Sandow,Yadav Sapkota,Naveed Sattar,Marjanka K. Schmidt,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Svati H. Shah,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Albert V. Smith,Jennifer A. Smith,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Valgerdur Steinthorsdottir,Heather M. Stringham,Michael Stumvoll,Praveen Surendran,Leen M 't Hart,Katherine E. Tansey,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Toenjes,Gerard Tromp,Stella Trompet,Emmanouil Tsafantakis,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Jonathan Tyrer,Rudolf Uher,André G. Uitterlinden,Sheila Ulivi,Sander W. van der Laan,Andries R. van der Leij,Cornelia M. van Duijn,Natasja M. van Schoor,Jessica van Setten,Anette Varbo,Tibor V. Varga,Rohit Varma,Digna R. Velez Edwards,Sita H. Vermeulen,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Diego Vozzi,Mark Walker,Feijie Wang,Carol A. Wang,Shuai Wang,Yiqin Wang,Nicholas J. Wareham,Helen R. Warren,Jennifer Wessel,Sara M. Willems,James G. Wilson,Daniel R. Witte,Michael O. Woods,Ying Wu,Hanieh Yaghootkar,Jie Yao,Pang Yao,Laura M. Yerges-Armstrong,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Jing Hua Zhao,Wei Zhao,He Zheng,Wei Zhou,Jerome I. Rotter,Michael Boehnke,Sekar Kathiresan,Mark I. McCarthy,Cristen J. Willer,Kari Stefansson,Ingrid B. Borecki,Dajiang J. Liu,Kari E. North,Nancy L. Heard-Costa,Tune H. Pers,Cecilia M. Lindgren,Claus Oxvig,Zoltán Kutalik,Fernando Rivadeneira,Ruth J. F. Loos,Timothy M. Frayling,Joel N. Hirschhorn,Panos Deloukas,Guillaume Lettre +370 more
- 01 Jan 2017
TL;DR: The results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Valérie Turcot,Yingchang Lu,Yingchang Lu,Heather M. Highland,Heather M. Highland,Claudia Schurmann,Anne E. Justice,Rebecca S. Fine,Rebecca S. Fine,Jonathan P. Bradfield,Tõnu Esko,Tõnu Esko,Tõnu Esko,Ayush Giri,Mariaelisa Graff,Xiuqing Guo,Audrey E. Hendricks,Audrey E. Hendricks,Tugce Karaderi,Tugce Karaderi,Adelheid Lempradl,Adam E. Locke,Adam E. Locke,Anubha Mahajan,Eirini Marouli,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Kristin L. Young,Tamuno Alfred,Mary F. Feitosa,Nicholas G. D. Masca,Nicholas G. D. Masca,Alisa K. Manning,Alisa K. Manning,Carolina Medina-Gomez,Poorva Mudgal,Maggie C.Y. Ng,Alexander P. Reiner,Alexander P. Reiner,Sailaja Vedantam,Sailaja Vedantam,Sara M. Willems,Thomas W. Winkler,Gonçalo R. Abecasis,Katja K.H. Aben,Dewan S. Alam,Sameer E. Al-Harthi,Sameer E. Al-Harthi,Matthew A. Allison,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Folkert W. Asselbergs,Folkert W. Asselbergs,Paul L. Auer,Beverley Balkau,Lia E. Bang,Inês Barroso,Inês Barroso,Lisa Bastarache,Marianne Benn,Sven Bergmann,Sven Bergmann,Lawrence F. Bielak,Matthias Blüher,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Eric Boerwinkle,Carsten A. Böger,Jette Bork-Jensen,Michiel L. Bots,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Gerome Breen,Gerome Breen,Murray H. Brilliant,Linda Broer,Marco Brumat,Amber A. Burt,Adam S. Butterworth,Peter T. Campbell,Stefania Cappellani,David J. Carey,Eulalia Catamo,Mark J. Caulfield,John C. Chambers,John C. Chambers,Daniel I. Chasman,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Audrey Y. Chu,Massimiliano Cocca,Francis S. Collins,James P. Cook,Janie Corley,Jordi Corominas Galbany,Amanda J. Cox,Amanda J. Cox,David S. Crosslin,Gabriel Cuellar-Partida,Gabriel Cuellar-Partida,Angela D'Eustacchio,John Danesh,John Danesh,Gail Davies,Gail Davies,Paul I.W. de Bakker,Mark C.H. De Groot,Renée de Mutsert,Ian J. Deary,Ian J. Deary,George Dedoussis,Ellen W. Demerath,Martin den Heijer,Anneke I. den Hollander,Hester M. den Ruijter,Joe Dennis,Josh C. Denny,Emanuele Di Angelantonio,Fotios Drenos,Fotios Drenos,Mengmeng Du,Mengmeng Du,Marie-Pierre Dubé,Alison M. Dunning,Douglas F. Easton,Todd L. Edwards,David Ellinghaus,Patrick T. Ellinor,Patrick T. Ellinor,Paul Elliott,Evangelos Evangelou,Evangelos Evangelou,Aliki-Eleni Farmaki,Aliki-Eleni Farmaki,I. Sadaf Farooqi,Jessica D. Faul,Sascha Fauser,Shuang Feng,Ele Ferrannini,Jean Ferrières,Jose C. Florez,Jose C. Florez,Ian Ford,Myriam Fornage,Oscar H. Franco,Andre Franke,Paul W. Franks,Paul W. Franks,Paul W. Franks,Nele Friedrich,Ruth Frikke-Schmidt,Tessel E. Galesloot,Wei Gan,Ilaria Gandin,Paolo Gasparini,Jane Gibson,Vilmantas Giedraitis,Anette P. Gjesing,Penny Gordon-Larsen,Mathias Gorski,Hans-Jörgen Grabe,Hans-Jörgen Grabe,Struan F.A. Grant,Niels Grarup,Helen Griffiths,Megan L. Grove,Vilmundur Gudnason,Stefan Gustafsson,Jeffrey Haessler,Hakon Hakonarson,Anke R. Hammerschlag,Torben Hansen,Kathleen Mullan Harris,Tamara B. Harris,Andrew T. Hattersley,Christian Theil Have,Caroline Hayward,Liang He,Liang He,Nancy L. Heard-Costa,Nancy L. Heard-Costa,Andrew C. Heath,Iris M. Heid,Øyvind Helgeland,Jussi Hernesniemi,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Yao Hu,Paul L. Huang,Jennifer E. Huffman,M. Arfan Ikram,Erik Ingelsson,Erik Ingelsson,Anne U. Jackson,Jan-Håkan Jansson,Gail P. Jarvik,Gorm B. Jensen,Yucheng Jia,Stefan Johansson,Marit E. Jørgensen,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,J. Wouter Jukema,Bratati Kahali,Bratati Kahali,René S. Kahn,Mika Kähönen,Pia R. Kamstrup,Stavroula Kanoni,Jaakko Kaprio,Jaakko Kaprio,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Sekar Kathiresan,Sekar Kathiresan,Frank Kee,Lambertus A. Kiemeney,Eric Kim,Hidetoshi Kitajima,Pirjo Komulainen,Jaspal S. Kooner,Jaspal S. Kooner,Charles Kooperberg,Tellervo Korhonen,Tellervo Korhonen,Tellervo Korhonen,Peter Kovacs,Helena Kuivaniemi,Helena Kuivaniemi,Zoltán Kutalik,Zoltán Kutalik,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,David Lamparter,David Lamparter,Ethan M. Lange,Leslie A. Lange,Claudia Langenberg,Eric B. Larson,Eric B. Larson,Nanette R. Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Honghuang Lin,Keng-Hung Lin,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Ching-Ti Liu,Dajiang J. Liu,Yongmei Liu,Ken Sin Lo,Artitaya Lophatananon,Andrew J. Lotery,Anu Loukola,Jian'an Luan,Steven A. Lubitz,Steven A. Lubitz,Leo-Pekka Lyytikäinen,Satu Männistö,Gaëlle Marenne,Angela L. Mazul,Mark I. McCarthy,Roberta McKean-Cowdin,Sarah E. Medland,Karina Meidtner,Lili Milani,Vanisha Mistry,Paul Mitchell,Karen L. Mohlke,Leena Moilanen,Marie Moitry,Grant W. Montgomery,Grant W. Montgomery,Dennis O. Mook-Kanamori,Carmel Moore,Trevor A. Mori,Andrew D. Morris,Andrew P. Morris,Andrew P. Morris,Martina Müller-Nurasyid,Patricia B. Munroe,Mike A. Nalls,Narisu Narisu,Christopher P. Nelson,Christopher P. Nelson,Matt Neville,Sune F. Nielsen,Kjell Nikus,Pål R. Njølstad,Børge G. Nordestgaard,Dale R. Nyholt,Dale R. Nyholt,Jeffrey R. O'Connel,Michelle L. O'Donoghue,Loes M. Olde Loohuis,Roel A. Ophoff,Roel A. Ophoff,Katharine R. Owen,Chris J. Packard,Sandosh Padmanabhan,Colin N. A. Palmer,Nicholette D. Palmer,Gerard Pasterkamp,Aniruddh P. Patel,Aniruddh P. Patel,Alison Pattie,Oluf Pedersen,Peggy L. Peissig,Gina M. Peloso,Craig E. Pennell,Markus Perola,Markus Perola,Markus Perola,James A. Perry,John R. B. Perry,Tune H. Pers,Tune H. Pers,Thomas N. Person,Annette Peters,Eva Rb Petersen,Patricia A. Peyser,Ailith Pirie,Ozren Polasek,Ozren Polasek,Tinca J. C. Polderman,Hannu Puolijoki,Olli T. Raitakari,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Frida Renström,Frida Renström,Myriam Rheinberger,Paul M. Ridker,John D. Rioux,Manuel A. Rivas,Manuel A. Rivas,David J. Roberts,David J. Roberts,David J. Roberts,Neil R. Robertson,Antonietta Robino,Olov Rolandsson,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Yadav Sapkota,Naveed Sattar,Robert E. Schoen,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Svati H. Shah,Wayne H-H Sheu,Wayne H-H Sheu,Xueling Sim,Xueling Sim,Andrew J. Slater,Kerrin S. Small,Albert V. Smith,Lorraine Southam,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Kari Stefansson,Kari Stefansson,Valgerdur Steinthorsdottir,Kathleen Stirrups,Kathleen Stirrups,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Liang Sun,Liang Sun,Praveen Surendran,Amy J. Swift,Hayato Tada,Hayato Tada,Katherine E. Tansey,Katherine E. Tansey,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Tönjes,Gerard Tromp,Gerard Tromp,Stella Trompet,Emmanouil Tsafantakis,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Jonathan Tyrer,Rudolf Uher,André G. Uitterlinden,Matti Uusitupa,Sander W. van der Laan,Cornelia M. van Duijn,Nienke van Leeuwen,Nienke van Leeuwen,Jessica van Setten,Mauno Vanhala,Anette Varbo,Tibor V. Varga,Rohit Varma,Digna R. Velez Edwards,Sita H. Vermeulen,Giovanni Veronesi,Henrik Vestergaard,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Uwe Völker,Dragana Vuckovic,Lynne E. Wagenknecht,Mark Walker,Lars Wallentin,Feijie Wang,Carol A. Wang,Shuai Wang,Yiqin Wang,Erin B. Ware,Nicholas J. Wareham,Helen R. Warren,Dawn M. Waterworth,Jennifer Wessel,Harvey D. White,Cristen J. Willer,James G. Wilson,Daniel R. Witte,Andrew R. Wood,Ying Wu,Hanieh Yaghootkar,Jie Yao,Pang Yao,Laura M. Yerges-Armstrong,Laura M. Yerges-Armstrong,Robin Young,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Wei Zhao,Wei Zhao,Wei Zhou,Krina T. Zondervan,Jerome I. Rotter,John Andrew Pospisilik,Fernando Rivadeneira,Ingrid B. Borecki,Panos Deloukas,Panos Deloukas,Timothy M. Frayling,Guillaume Lettre,Kari E. North,Cecilia M. Lindgren,Joel N. Hirschhorn,Joel N. Hirschhorn,Ruth J. F. Loos +489 more
TL;DR: Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index that confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Jennifer Wessel,Audrey Y. Chu,Sara M. Willems,Shuai Wang,Hanieh Yaghootkar,Jennifer A. Brody,Marco Dauriz,Sridharan Raghavan,Leonard Lipovich,Bertha Hidalgo,Keolu Fox,Jennifer E. Huffman,Ping An,Yingchang Lu,Laura J. Rasmussen-Torvik,Niels Grarup,Margaret G. Ehm,Li Li,Abigail S. Baldridge,Alena Stančáková,Ravinder Abrol,Céline Besse,Anne Boland,Jette Bork-Jensen,Myriam Fornage,Daniel F. Freitag,Melissa E. Garcia,Xiuqing Guo,Hara Kazuo,Aaron Isaacs,Johanna Jakobsdottir,Leslie A. Lange,Jill Layton,Man Li,Jing Hua Zhao,Karina Meidtner,Alanna C. Morrison,Mike A. Nalls,Marjolein J. Peters,Maria Sabater-Lleal,Claudia Schurmann,Angela Silveira,Albert V. Smith,Lorraine Southam,Marcus H. Stoiber,Rona J. Strawbridge,Kent D. Taylor,Tibor V. Varga,Kristine H. Allin,Najaf Amin,Jennifer L. Aponte,Tin Aung,Caterina Barbieri,Nathan A. Bihlmeyer,Michael Boehnke,Cristina Bombieri,Donald W. Bowden,Sean M. Burns,Yuning Chen,Yii Deri Chen,Ching-Yu Cheng,Adolfo Correa,Jacek Czajkowski,Abbas Dehghan,Georg Ehret,Gudny Eiriksdottir,Stefan A. Escher,Aliki-Eleni Farmaki,Mattias Frånberg,Giovanni Gambaro,Franco Giulianini,William A. Goddard,Anuj Goel,Omri Gottesman,Megan L. Grove,Stefan Gustafsson,Yang Hai,Göran Hallmans,Jiyoung Heo,Per Hoffmann,Mohammad Kamran Ikram,Richard A. Jensen,Marit E. Jørgensen,Torben Jørgensen,Maria Karaleftheri,Chiea Chuen Khor,Andrea Kirkpatrick,Aldi T. Kraja,Johanna Kuusisto,Ethan M. Lange,I-Te Lee,Wen Jane Lee,Aaron Leong,Jiemin Liao,Chunyu Liu,Yongmei Liu,Cecilia M. Lindgren,Allan Linneberg,Giovanni Malerba,Vasiliki Mamakou,Eirini Marouli,Nisa M. Maruthur,Angela Matchan,Roberta McKean-Cowdin,Olga McLeod,Ginger A. Metcalf,Karen L. Mohlke,Donna M. Muzny,Ioanna Ntalla,Nicholette D. Palmer,Dorota Pasko,Andreas Peter,Nigel W. Rayner,Frida Renström,Kenneth Rice,Cinzia Sala,Bengt Sennblad,Ioannis Serafetinidis,Jennifer A. Smith,Nicole Soranzo,Elizabeth K. Speliotes,Eli A. Stahl,Kathleen Stirrups,Nikos Tentolouris,Anastasia Thanopoulou,Mina Torres,Michela Traglia,Emmanouil Tsafantakis,Sundas Javad,Lisa R. Yanek,Eleni Zengini,Diane M. Becker,Joshua C. Bis,James B. Brown,L. Adrienne Cupples,Torben Hansen,Erik Ingelsson,Andrew J. Karter,Carlos Lorenzo,Rasika A. Mathias,Jill M. Norris,Gina M. Peloso,Wayne Huey-Herng Sheu,Daniela Toniolo,Dhananjay Vaidya,Rohit Varma,Lynne E. Wagenknecht,Heiner Boeing,Erwin P. Bottinger,George Dedoussis,Panos Deloukas,Ele Ferrannini,Oscar H. Franco,Paul W. Franks,Richard A. Gibbs,Vilmundur Gudnason,Anders Hamsten,Tamara B. Harris,Andrew T. Hattersley,Caroline Hayward,Albert Hofman,Jan-Håkan Jansson,Claudia Langenberg,Lenore J. Launer,Daniel Levy,Ben A. Oostra,Christopher J. O'Donnell,Stephen O'Rahilly,Sandosh Padmanabhan,James S. Pankow,Ozren Polasek,Michael A. Province,Stephen S. Rich,Paul M. Ridker,Igor Rudan,Matthias B. Schulze,Blair H. Smith,André G. Uitterlinden,Mark Walker,Hugh Watkins,Tien Yin Wong,Eleftheria Zeggini,Markku Laakso,Ingrid B. Borecki,Daniel I. Chasman,Oluf Pedersen,Bruce M. Psaty,E. Shyong Tai,Cornelia M. van Duijn,Nicholas J. Wareham,Dawn M. Waterworth,Eric Boerwinkle,W. H. Linda Kao,Jose C. Florez,Ruth J. F. Loos,James G. Wilson,Timothy M. Frayling,David S. Siscovick,Josée Dupuis,Jerome I. Rotter,James B. Meigs,Robert A. Scott,Mark O. Goodarzi +202 more
TL;DR: In this article, the role of coding variation on intermediate traits for type 2 diabetes was explored by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls.
The transferability of lipid loci across African, Asian and European cohorts
Karoline Kuchenbaecker,Nikita Telkar,Theresa Reiker,Robin G Walters,Kuang Lin,Anders Eriksson,Deepti Gurdasani,Arthur Gilly,Lorraine Southam,Lorraine Southam,Emmanouil Tsafantakis,Maria Karaleftheri,Janet Seeley,Anatoli Kamali,Gershim Asiki,Gershim Asiki,Iona Y Millwood,Iona Y Millwood,Michael V. Holmes,Michael V. Holmes,Huaidong Du,Huaidong Du,Yu Guo,Meena Kumari,George Dedoussis,Liming Li,Zhengming Chen,Manjinder S. Sandhu,Eleftheria Zeggini +28 more
TL;DR: It is found that the major lipid loci are mostly transferrable between Europeans and Asians while there are notable exceptions for African populations.