Emma Laporte
Katholieke Universiteit Leuven
9 Papers
20 Citations
Emma Laporte is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Stem cell & Medicine. The author has an hindex of 2, co-authored 3 publications.
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Papers
Organoids from pituitary as a novel research model toward pituitary stem cell exploration.
Benoit Cox,Emma Laporte,Annelies Vennekens,Hiroto Kobayashi,Hiroto Kobayashi,Charlotte Nys,Indra Van Zundert,Hiroshi Uji-i,Alizée Vercauteren Drubbel,Benjamin Beck,Heleen Roose,Matteo Boretto,Hugo Vankelecom +12 more
TL;DR: A novel organoid research model is established revealing new insights into the identity and regulation of the putative pituitary stem cells, which may eventually lead to an interesting tool to decipher pituitsary stem cell biology in both healthy and diseased gland.
Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland.
Annelies Vennekens,Emma Laporte,Florient Hermans,Florient Hermans,Benoit Cox,Elodie Modave,Elodie Modave,Adrian Janiszewski,Charlotte Nys,Hiroto Kobayashi,Hiroto Kobayashi,Bert Malengier-Devlies,Joel Chappell,Patrick Matthys,Marie-Isabelle Garcia,Vincent Pasque,Diether Lambrechts,Diether Lambrechts,Hugo Vankelecom +18 more
TL;DR: In this paper, single-cell RNA sequencing uncovered interleukin-6 (IL-6) as being upregulated upon damage, however only in young but not aging pituitary.
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Pituitary Remodeling Throughout Life: Are Resident Stem Cells Involved?
TL;DR: The pituitary gland has the primordial ability to dynamically adapt its cell composition to changing hormonal needs of the organism throughout life as mentioned in this paper, and the underlying molecular mechanisms of the stem cell-linked ones are still largely unknown.
Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology.
TL;DR: It is shown that mouse pituitary-derived organoids develop from the gland's stem cells and faithfully recapitulate their in vivo phenotypic and functional characteristics, and reproduce the activation state of the stem cells as in vivo occurring in response to transgenically inflicted local damage.
The human pituitary master gland stripped to single-cell resolution
Emma Laporte,Hugo Vankelecom +1 more
TL;DR: This article applied transcriptome and chromatin accessibility profiling at single-cell resolution to human postmortem pituitary glands from individuals of different ages, thereby providing insights into the heterogeneity and regulatory mechanisms of the projected human Pituitary stem cell population.