5 Papers
Emma Davis is an academic researcher from Australian Nuclear Science and Technology Organisation. The author has contributed to research in topics: Translocator protein & Imaging phantom. The author has an hindex of 3, co-authored 5 publications.
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Papers
Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
Richard B. Banati,Ryan J. Middleton,Ronald Chan,Claire R. Hatty,Winnie Wai-Ying Kam,Candice Quin,Manuel B. Graeber,Arvind Parmar,David Zahra,Paul D. Callaghan,Sandra Fok,Nicholas R. Howell,Marie Gregoire,Alexander M Szabo,Tien Pham,Emma Davis,Guo Jun Liu,Guo Jun Liu +17 more
TL;DR: It is shown that global C57BL/6-Tspotm1GuWu(GuwiyangWurra)-knockout mice are viable with normal growth, lifespan, cholesterol transport, blood pregnenolone concentration, protoporphyrin IX metabolism, fertility and behaviour, and while the activation of microglia after neuronal injury appears to be unimpaired, microglial output is significantly less ATP, suggesting reduced metabolic activity.
Muscle and carapace tissue-diet isotope discrimination factors for the freshwater crayfish Cherax destructor
TL;DR: This study examined a range of diets and two tissue types of Cherax destructor to allow more accurate use of isotope data in trophic source estimates, indicating that carapace can be used as a non-lethal alternative to muscle during field sampling.
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Simultaneous scanning of two mice in a small-animal PET scanner: a simulation-based assessment of the signal degradation.
Anthonin Reilhac,Anthonin Reilhac,Frederic Boisson,Catriona Wimberley,Catriona Wimberley,Arvind Parmar,Arvind Parmar,David Zahra,Hasar Hamze,Emma Davis,Andrew Arthur,Caroline Bouillot,Arnaud Charil,Arnaud Charil,Marie-Claude Gregoire,Marie-Claude Gregoire +15 more
TL;DR: This is the first study showing the impact of different experimental designs for whole-body and brain acquisitions of two mice on the quality of the results using Monte Carlo simulated [18F]FDG and [11C]Raclopride PET studies.
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Synthesis and biological characterisation of 18F-SIG343 and 18F-SIG353, novel and high selectivity σ2 radiotracers, for tumour imaging properties.
Vu Nguyen,Tien Pham,Chris Fookes,Paula Berghofer,Ivan Greguric,Andrew Arthur,Filomena Mattner,Filomena Mattner,Gita Rahardjo,Emma Davis,Nicholas R. Howell,Marie-Claude Gregoire,Andrew Katsifis,Andrew Katsifis,Rachael Shepherd +14 more
TL;DR: The lead ligands showed promising in vitro and in vivo characteristics, however, PET imaging indicated low tumour-to-background ratios and longer scans using appropriate half-life isotopes and alternative tumour models will be carried out in future studies to fully validate the imaging characteristics of these radiotracers.
Mitochondrial Translocator Protein (TSPO) Expression in the Brain After Whole Body Gamma Irradiation.
Calina Betlazar,Calina Betlazar,Ryan J. Middleton,Nicholas R. Howell,Ben Storer,Emma Davis,Justin Davies,Richard B. Banati,Richard B. Banati,Guo Jun Liu,Guo Jun Liu +10 more
TL;DR: In this paper, the authors explored the use of TSPO as a biomarker of brain tissue injury following whole body irradiation and found that acute low and high doses of gamma irradiation up to 2 Gy reduced the expression in the brain parenchymal microglia.