Emma Bell
German Cancer Research Center
31 Papers
155 Citations
Emma Bell is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Neuroblastoma & Biology. The author has an hindex of 19, co-authored 28 publications. Previous affiliations of Emma Bell include AstraZeneca & University of York.
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Papers
Telomerase activation by genomic rearrangements in high-risk neuroblastoma
Martin Peifer,Falk Hertwig,Frederik Roels,Daniel Dreidax,Moritz Gartlgruber,Roopika Menon,Andrea Krämer,Justin L. Roncaioli,Frederik Sand,Johannes M. Heuckmann,Fakhera Ikram,Rene Schmidt,Sandra Ackermann,Anne Engesser,Yvonne Kahlert,Wenzel Vogel,Janine Altmüller,Peter Nürnberg,Jean Thierry-Mieg,Danielle Thierry-Mieg,Aruljothi Mariappan,Stefanie Heynck,Erika Mariotti,Kai-Oliver Henrich,Christian Gloeckner,Graziella Bosco,Ivo Leuschner,Michal R. Schweiger,Larissa Savelyeva,Simon C. Watkins,Chunxuan Shao,Emma Bell,Thomas Höfer,Viktor Achter,Ulrich Lang,Jessica Theissen,Ruth Volland,Maral Saadati,Angelika Eggert,Bram De Wilde,Frank Berthold,Zhiyu Peng,Chen Zhao,Leming Shi,Monika Ortmann,Reinhard Büttner,Sven Perner,Barbara Hero,Alexander Schramm,Johannes H. Schulte,Johannes H. Schulte,Carl Herrmann,Carl Herrmann,Roderick J. O’Sullivan,Frank Westermann,Roman K. Thomas,Matthias G. Fischer +56 more
TL;DR: It is shown that remodelling of the genomic context abrogates transcriptional silencing of TERT in high-risk neuroblastoma and places telomerase activation in the centre of transformation in a large fraction of these tumours.
Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition
Anton G. Henssen,Anton G. Henssen,Kristina Althoff,Andrea Odersky,Anneleen Beckers,Richard Koche,Frank Speleman,Simon Schäfers,Emma Bell,Maike Nortmeyer,Frank Westermann,Katleen De Preter,Alexandra Florin,Lukas C. Heukamp,Annika Spruessel,Kathy Astrahanseff,Sven Lindner,Natalie Sadowski,Alexander Schramm,Lucile Astorgues-Xerri,Maria E. Riveiro,Angelika Eggert,Esteban Cvitkovic,Johannes H. Schulte +23 more
TL;DR: It is shown that OTX015 is effective against mouse and human MYCN-driven tumor models and that BRD4 not only targets MYCN, but specifically occupies MYCN target gene enhancers as well as other genes associated with super-enhancers.
A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours
Matthew J. Murray,Emma Bell,Emma Bell,Katie L. Raby,Martin A. Rijlaarsdam,Ad J. M. Gillis,Leendert H. J. Looijenga,Helen Brown,Benoit Destenaves,James Nicholson,Nicholas Coleman +10 more
TL;DR: A robust technical pipeline to quantify miRNAs in the serum and cerebrospinal fluid and allowed early detection of relapse of a testicular mixed malignant GCT; and distinguished intracranial malignantGCT from intrac Cranial non-GCT tumours at diagnosis, using CSF and serum samples are developed.
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis
Hamed Alborzinia,Andrés F. Flórez,Sina Kreth,L.M. Brückner,Umut Yildiz,Moritz Gartlgruber,Dorett I Odoni,Gernot Poschet,Karolina Garbowicz,Chunxuan Shao,Corinna Klein,Jasmin Meier,Petra Zeisberger,Michal Nadler-Holly,Matthias Ziehm,Franziska Paul,Jürgen Burhenne,Emma Bell,Marjan Shaikhkarami,Roberto Würth,Sabine A Stainczyk,Elisa M Wecht,Jochen Kreth,Michael Büttner,Naveed Ishaque,Matthias Schlesner,Barbara Nicke,Carlo Stresemann,Maria Llamazares Prada,Jan H. Reiling,Matthias Fischer,Ido Amit,Matthias Selbach,Carl Herrmann,Stefan Wölfl,Kai Oliver Henrich,Thomas Höfer,Andreas Trumpp,Frank Westermann +38 more
TL;DR: In this article , pharmacological inhibition of both cystine uptake and transsulfuration combined with GPX4 inactivation resulted in tumor remission in an orthotopic MYCN-amplified neuroblastoma model.
Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas.
Kai Oliver Henrich,Sebastian Bender,Maral Saadati,Daniel Dreidax,Moritz Gartlgruber,Chunxuan Shao,Carl Herrmann,Manuel Wiesenfarth,Martha Parzonka,Lea Wehrmann,Matthias Fischer,David J. Duffy,Emma Bell,Alica Torkov,Peter Schmezer,Christoph Plass,Thomas Höfer,Axel Benner,Stefan M. Pfister,Frank Westermann +19 more
TL;DR: It is found that DNA methylation patterns identify divergent patient subgroups with respect to survival and clinicobiologic variables, and intragenic enhancer methylation as a mechanism for high-risk-associated transcriptional deregulation in high- risk neuroblastomas.