Emily Brown
5 Papers
Emily Brown is an academic researcher. The author has contributed to research in topics: Biology & Proteomics. The author has co-authored 4 publications.
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Papers
A complete pipeline for high‐plex spatial proteomic profiling and analysis of neural cell phenotypes on the CosMx™ Spatial Molecular Imager and AtoMx™ Spatial Informatics Platform
Alyssa Rosenbloom,Shilah A. Bonnett,Mark Conner,Tien Phan-Everson,Zachary R. Lewis,Giang T. Ong,Yan Liang,Emily Brown,Aster Wardhani,Mithra Korukonda,Carl O. Brown,Dwayne Dunaway,Edward Zhao,Dan McGuire,Sangsoon Woo,Brian Filanoski,Rhonda Meredith,Kan Chantranuvatana,Brian Birditt,Hyeri Yi,Erin Piazza,J. Reeves,Gary Geiss,Joseph Beechem +23 more
- 01 Dec 2023
TL;DR: The ability to explore protein‐driven activities at high resolution within spatial context of their immediate environment is critical to gain comprehensive pictures of brain development, activity, aging, disease or dysfunction, and inflammatory responses.
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Abstract 5641: Single cell spatial molecular imaging of 76-plex proteins in clinical cancer samples in response to personalized treatment
Zachary R. Lewis,Brian Birditt,Emily Brown,Kan Chantranuvatana,Brian Filanoski,Christopher L. Corless,Tien Phan-Everson,Gary K. Geiss,Tyler Hether,Evie Hobbs,Brett Johnson,Taylor Kelley,Rhonda Meredith,Anastasiya Olson,Giang T. Ong,Mithra Korukonda,Erin Piazza,Jason Reeves,Alyssa B. Rosenbloom,Kiara Siex,Hyeri Yi,Edward Zhao,Joseph M. Beechem,Gordon B. Mills +23 more
TL;DR: In this article , the authors demonstrate the ability of the CosMx platform to quantify more than 70 proteins encompassing key targets in immuno-oncology and tumor biology, localize the proteins and analyze protein expression at a single cell level.
2
Abstract 4617: A complete pipeline for high-plex spatial proteomic profiling and analysis on the cosmxtm spatial molecular imager and atomtm spatial informatics platform
Tien Phan-Everson,Zachary R. Lewis,Giang T. Ong,Yang Xiang,Emily Brown,Liuliu Pan,Aster Wardhani,Mithra Korukonda,Carl O. Brown,Dwayne Dunaway,Edward Zhao,Sangsoon Woo,Alyssa B. Rosenbloom,Brian Filanoski,Rhonda Meredith,Kan Chantranuvatana,Brian Birditt,Hyeri Yi,Erin Piazza,Jason Reeves,John S. Lyssand,Vik Devgan,Michael Rhodes,Gary K. Geiss,Joseph M. Beechem +24 more
TL;DR: The AtoMx spatial molecular imager (SMI) as discussed by the authors is a high-level spatial multi-omics platform that enables detection of more than 110 proteins at subcellular resolution in real-world FFPE tissues.
951 Spatial atlases of immunological development within the lymph node
Tyler Hether,Stephanie Zimmerman,Zachary R. Lewis,Shan He,Liang Zhang,Kathy Ton,Liuliu Pan,Wei Yang,Stefan J. Phelan,Charlie Glaser,Andrew Nam,Emily Brown,Michael Patrick,Gary K. Geiss,S. Church,Michael Rhodes,Yan Liang,Jason Reeves,Joseph M. Beechem +18 more
- 01 Nov 2022
TL;DR: In this article , the authors used a semi-supervised clustering algorithm to map cells to CosMx from lymph node scRNAseq, which was confirmed with protein profiling with GeoMx.
147 Comprehensivein situimmune phenotyping with the CosMx™ high plex protein assay
Tien Phan-Everson,Jianji Chen,Zachary R. Lewis,Gary K. Geiss,Yang Xiang,Emily Brown,Liuliu Pan,Stefan J. Phelan,Charlie Glaser,Mithra Korukonda,Carl O. Brown,Dwayne Dunaway,Joseph C. Phan,Alyssa B. Rosenbloom,Brian Filanoski,Rhonda Meredith,Kan Chantranuvatana,Brian Birditt,Giang T. Ong,Hyeri Yi,Erin Piazza,Jason Reeves,Subham Basu,Christine H Kang,Vikram Devgan,Edward Zhao,M. Rhodes,Joseph M. Beechem +27 more
- 01 Nov 2022
TL;DR: The CosMx SMI platform as mentioned in this paper uses antibodies conjugated with oligonucleotides, which are detected using universal, multi-analyte cosMx readout reagents.