Emilio Lecona

TL;DR: The links between replication stress (RS) and cancer are reviewed, which provide a rationale for the use of ATR and Chk1 inhibitors in chemotherapy, and the evidence showing that tumors with high levels of RS are dependent on a proficient RS-response, and therefore vulnerable to ATR or Chk 1 inhibitors is summarized.

TL;DR: It is shown that ES suffer from high endogenous levels of RS, rendering them particularly dependent on the ATR pathway, and ATR inhibitors are identified as a potential therapy for Ewing Sarcomas.

TL;DR: It is shown thatSCML2A, an SCML2 isoform tightly associated to chromatin, contributes to PRC1 localization and also directly enforces repression of certain Polycomb target genes, pointing to a role for ncRNAs in regulating SC ML2 function and suggest that SCML 2 participates in the epigenetic control of transcription directly and in cooperation withPRC1.

TL;DR: In this article, the deubiquitinase USP7 inhibitors induce a widespread activation of CDK1 throughout the cell cycle, which leads to DNA damage and is toxic for mammalian cells.