Emile Hashem
University of Ottawa
3 Papers
4 Citations
Emile Hashem is an academic researcher from University of Ottawa. The author has contributed to research in topics: Chromatin remodeling & Chromatin. The author has an hindex of 2, co-authored 3 publications. Previous affiliations of Emile Hashem include Ottawa Hospital Research Institute.
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Papers
Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation
Matías Alvarez-Saavedra,Matías Alvarez-Saavedra,Yves De Repentigny,Pamela S. Lagali,Edupuganti V.S. Raghu Ram,Keqin Yan,Emile Hashem,Emile Hashem,Danton Ivanochko,Danton Ivanochko,Michael S. Huh,Doo Yang,Alan J. Mears,Matthew A. M. Todd,Matthew A. M. Todd,Chelsea P. Corcoran,Erin A. Bassett,Nicholas Tokarew,Juraj Kokavec,Romit Majumder,Ilya Ioshikhes,Valerie A. Wallace,Valerie A. Wallace,Rashmi Kothary,Rashmi Kothary,Eran Meshorer,Tomas Stopka,Arthur I. Skoultchi,David J. Picketts,David J. Picketts +29 more
TL;DR: It is shown that mice conditionally inactivated for Snf2h in neural progenitors have reduced levels of histone H1 and H2A variants that compromise chromatin fluidity and transcriptional programs within the developing cerebellum.
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Coordinated epigenetic regulation of Engrailed-1 by the chromatin remodelers Smarca1 and Smarca5 mediates cerebellar morphogenesis
Matías Alvarez-Saavedra,Matías Alvarez-Saavedra,Pamela S. Lagali,Keqin Yan,Emile Hashem,Emile Hashem,Alan J. Mears,Yves De Repentigny,Valerie A. Wallace,Valerie A. Wallace,Rashmi Kothary,Rashmi Kothary,Tomas Stopka,Arthur I. Skoultchi,David J. Picketts,David J. Picketts +15 more
TL;DR: It is shown that the Iswi chromatin remodeling proteins, Smarca5 and SmarcA1, are required for the dynamic regulation of Engrailed-1 (En1), and during late cerebellar development, co-binding of the IsWI proteins at the En1 locus and an altered H2AZ/ H3.3 chromatin profile that accompanies changes in En1 expression.
The Psychometric Properties of a Self-Administered, Open-Source Module for Valuing Metastatic Epidural Spinal Cord Compression Utilities.
Markian A. Pahuta,Aaron Frombach,Emile Hashem,Stewart Spence,Christina Sun,Eugene K. Wai,Joel Werier,Carl van Walraven,Doug Coyle +8 more
- 01 Jun 2019
TL;DR: This study has demonstrated the SOAP MESCC module is valid, reproducible, and responsive for obtaining ex ante utilities, and is the first validated open-source, web-based, self-directed utility valuation module.