Emi Tsukamoto
Keio University
5 Papers
111 Citations
Emi Tsukamoto is an academic researcher from Keio University. The author has contributed to research in topics: Humanin & Programmed cell death. The author has an hindex of 5, co-authored 5 publications.
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Papers
Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death.
Yuichi Hashimoto,Osahiko Tsuji,Takako Niikura,Yohichi Yamagishi,Miho Ishizaka,Masaoki Kawasumi,Tomohiro Chiba,Kohsuke Kanekura,Marina Yamada,Emi Tsukamoto,Keisuke Kouyama,Kenzo Terashita,Sadakazu Aiso,Anning Lin,Ikuo Nishimoto +14 more
TL;DR: It is demonstrated that JNK is involved in APP‐mediated neuronal cell death as a downstream signal transducer of Go, and the pharmacological profile of caJNK‐mediated cell death closely coincided with that of APP‐ mediated cell death.
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Characterization of the toxic mechanism triggered by Alzheimer's amyloid‐β peptides via p75 neurotrophin receptor in neuronal hybrid cells
TL;DR: It is reported that Aβ causes cell death in neuronal hybrid cells transfected with p 75NTR, but not in nontransfected cells, and that p75NTRL401K cannot mediate Aβ neurotoxicity.
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The Cytoplasmic Domain of Alzheimer's Amyloid-β Protein Precursor Causes Sustained Apoptosis Signal-Regulating Kinase 1/c-Jun NH2-Terminal Kinase-Mediated Neurotoxic Signal via Dimerization
Yuichi Hashimoto,Takako Niikura,Tomohiro Chiba,Emi Tsukamoto,Hisae Kadowaki,Hideki Nishitoh,Yohichi Yamagishi,Miho Ishizaka,Marina Yamada,Mikiro Nawa,Kenzo Terashita,Sadakazu Aiso,Hidenori Ichijo,Ikuo Nishimoto +13 more
TL;DR: Data indicate that dimerization of AβPPCD triggers ASK1/JNK-mediated neuronal cell death, which allows for the achievement of cell death by short-term anti-AβPP antibody treatment.
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Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid‐β peptides via p75NTR/PLAIDD
Yuichi Hashimoto,Yuka Kaneko,Emi Tsukamoto,Harald Frankowski,Keisuke Kouyama,Yoshiko Kita,Takako Niikura,Sadakazu Aiso,Dale E. Bredesen,Dale E. Bredesen,Masaaki Matsuoka,Ikuo Nishimoto +11 more
TL;DR: It is shown that PLAIDD and Gi proteins, heterotrimeric G proteins, are involved in the alternative Aβ‐induced neurotoxicity mediated by p75NTR, and that HN, ADNF, IGF‐I, or bFGF inhibits both pathways.
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Amino- and Carboxyl-Terminal Mutants of Presenilin 1 Cause Neuronal Cell Death Through Distinct Toxic Mechanisms: Study of 27 Different Presenilin 1 Mutants
Yuichi Hashimoto,Emi Tsukamoto,Takako Niikura,Yohichi Yamagishi,Miho Ishizaka,Sadakazu Aiso,Akihiko Takashima,Ikuo Nishimoto +7 more
TL;DR: It is indicated for the first time that N‐ and C‐terminal fragment PS1 mutants can generate distinct neurot toxic signals, which will provide an important clue to the understanding of the entire array of neurotoxic signals generated by FAD‐causative mutations of PS1.
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