Emanuela Ognio
University of Genoa
24 Papers
155 Citations
Emanuela Ognio is an academic researcher from University of Genoa. The author has contributed to research in topics: Angiogenesis & Cytokine. The author has an hindex of 18, co-authored 24 publications.
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Papers
A novel liposomal Clodronate depletes tumor-associated macrophages in primary and metastatic melanoma: Anti-angiogenic and anti-tumor effects
Francesca Piaggio,Vangelis Kondylis,Fabio Pastorino,Daniela Di Paolo,Patrizia Perri,Irene Cossu,Fabian Schorn,Christian Marinaccio,Daniele Murgia,Antonio Daga,Federica Raggi,Monica Loi,Laura Emionite,Emanuela Ognio,Manolis Pasparakis,Domenico Ribatti,Mirco Ponzoni,Chiara Brignole +17 more
TL;DR: The depletion of TAMs in primary and metastatic melanoma presents anti-tumor efficacy via inhibition of angiogenesis and modulation of inflammation related cytokines through inhibited proliferation, reduced viability and induced apoptosis of a macrophage-like cell line in a dose- and time-dependent manner.
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Interleukin-27 Acts as Multifunctional Antitumor Agent in Multiple Myeloma
Claudia Cocco,Nicola Giuliani,Emma Di Carlo,Emanuela Ognio,Paola Storti,Manuela Abeltino,Carlo Sorrentino,Maurilio Ponzoni,Domenico Ribatti,Irma Airoldi +9 more
TL;DR: Findings show that IL-27 may represent a novel therapeutic agent capable of inhibiting directly MM cell growth as well as osteoclast differentiation and activity.
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•Journal Article
Embryotoxicity of Benzo(a)pyrene and Some of Its Synthetic Derivatives in Swiss Mice
TL;DR: The results combined with previous data concerning the induction of lung tumors by the tested compounds in 15-day-old Swiss mouse embryos, emphasize the requirement of a common metabolic derivative of BP to induce both teratogenesis and carcinogenesis in mice.
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Interleukin-27 inhibits pediatric B-acute lymphoblastic leukemia cell spreading in a preclinical model
S Canale,Claudia Cocco,Chiara Frasson,E Seganfreddo,E. Di Carlo,Emanuela Ognio,Carlo Sorrentino,Domenico Ribatti,Alessia Zorzoli,Giuseppe Basso,Carlo Dufour,Irma Airoldi +11 more
TL;DR: It is shown for the first time that pediatric B-ALL cells functional IL- 27R and that IL-27 dampens directly tumor growth in vivo and in vitro through mechanisms elucidated in this study.
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Interleukin-27 Inhibits the Growth of Pediatric Acute Myeloid Leukemia in NOD/SCID/Il2rg−/− Mice
Alessia Zorzoli,Emma Di Carlo,Claudia Cocco,Emanuela Ognio,Domenico Ribatti,Elisa Ferretti,Carlo Dufour,Franco Locatelli,Daniela Montagna,Irma Airoldi +9 more
TL;DR: The first demonstration that AML cells injected into NOD/SCID/Il2rg−/− mice gave rise to leukemia dissemination that was severely hampered by IL-27 is provided, providing an experimental rationale for the development of future clinical trials aimed at evaluating the toxicity and efficacy of IL- 27.
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