Elsebeth Andersen
Novartis
12 Papers
114 Citations
Elsebeth Andersen is an academic researcher from Novartis. The author has contributed to research in topics: Epitope & Allotransplantation. The author has an hindex of 9, co-authored 12 publications.
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Papers
Molecular mechanisms of immunosuppression.
Götz Baumann,Gerhard Zenke,Roland H. Wenger,Peter Hiestand,Valérie F. J. Quesniaux,Elsebeth Andersen,Max H. Schreier +6 more
TL;DR: It is found that CsA binding to its intracellular receptor (cyclophilin) is required but not sufficient for immunosuppression, and a significant understanding of the structure-activity relationship of Cs a has emerged.
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Molecular mechanisms of immunosuppression by cyclosporins.
Gerhard Zenke,Götz Baumann,Roland H. Wenger,Peter Hiestand,Valérie F. J. Quesniaux,Elsebeth Andersen,Max H. Schreier +6 more
TL;DR: It is shown that binding to cyclophilin is required, but not sufficient for immunosuppression, and derivatives of cyclosporin derivatives inhibit the isomerase activity of cyclophILin, which clearly demonstrates that inhibition of the cyclophillin isomerases activity does not lead to immunosppression.
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IL-2 promoter-driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice
Frank Brombacher,Thomas Schäfer,Ulrike Weissenstein,Claude Tschopp,Elsebeth Andersen,Kurt Bürki,Götz Baumann +6 more
TL;DR: It is demonstrated that IL-2 promoter-driven reporter gene expression in transgenic mice is a sensitive tool to characterize IL-1 expressing cells phenotypically and regulated expression of the transgene is comparable with that of the endogenousIL-2 gene.
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Aromatic quinolinecarboxamides as selective, orally active antibody production inhibitors for prevention of acute xenograft rejection.
Christos Papageorgiou,Anette Von Matt,Joanne Joergensen,Elsebeth Andersen,Katrin Wagner,Christian Beerli,Thai Than,Xaver Borer,Andrea Florineth,Gretty Rihs,Max H. Schreier,Gisbert Weckbecker,Christoph Heusser +12 more
TL;DR: The quinoline-8-carboxamide 3 was designed as a potentially weak enzyme inhibitor but effective immunosuppressant that effectively blocked TI-1 Ab production and suppressed Ab-mediated xenograft rejection in a xenotransplantation model under a once-daily dosing regimen.
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A cocktail of three monoclonal antibodies significantly increases the sensitivity of an enzyme immunoassay for human granulocyte-macrophage colony-stimulating factor.
Gerhard Zenke,Ulrike Strittmatter,R. Tees,Elsebeth Andersen,Barbara Fagg,Hans P. Kocher,Max H. Schreier +6 more
TL;DR: A sensitive and specific two-site ELISA was developed for human granulocyte-macrophage colony-stimulating factor (huGM-CSF) based on monoclonal antibodies which have been selected for high affinities and different epitope specificities and a major increase in sensitivity was achieved.
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