Els Decoster
Laboratory of Molecular Biology
9 Papers
199 Citations
Els Decoster is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Tumor necrosis factor alpha & Autocrine signalling. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of Els Decoster include Ghent University.
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Papers
Generation and biological characterization of membrane-bound, uncleavable murine tumor necrosis factor.
TL;DR: In this paper, mutational analysis of potential cleavage sites in murine TNF was carried out to compare the biological activity of membrane-bound versus soluble TNF, and the results indicated that membrane-based TNF cannot be passed from the 75kDa to the 55-kDa TNF receptor.
141
•Journal Article
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis
Walter Fiers,Rudi Beyaert,Elke Boone,Sigrid Cornelis,Wim Declercq,Els Decoster,Geertrui Denecker,B Depuydt,D. De Valck,G. De Wilde,V. Goossens,J. Grooten,Guy Haegeman,Karen Heyninck,Louis C. Penning,Stéphane Plaisance,Katia Vancompernolle,W. Van Criekinge,Peter Vandenabeele,W. Vanden Berghe,M. Van De Craen,Veronique Vandevoorde,Dominique Vercammen +22 more
TL;DR: In the mouse, seven cysteine proteases of the IHO family have been cloned and partially characterized and one substrate, which may be a key effector molecule in the apoptotic process, is PITSLRE kinase.
109
•Journal Article
Expression of an exogenous tumor necrosis factor (TNF) gene in TNF-sensitive cell lines confers resistance to TNF-mediated cell lysis.
Bart Vanhaesebroeck,Els Decoster,X. Van Ostade,S. Van Bladel,A. Lenaerts,F. Van Roy,Walter Fiers +6 more
TL;DR: Findings show that the membrane-bound TNF presequence as such is not sufficient for induction of TNF resistance and imply that the active site of mature TNF is involved in modulation of T NF responsiveness upon autocrine TNF production.
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Induction of unresponsiveness to tumor necrosis factor (TNF) after autocrine TNF expression requires TNF membrane retention.
Els Decoster,Bart Vanhaesebroeck,Elke Boone,Stéphane Plaisance,Kurt J. De Vos,Guy Haegeman,J. Grooten,Walter Fiers +7 more
TL;DR: The role of the TNF presequence in the induction of TNF unresponsiveness only involves its function as a membrane anchor, which permits oligomerization of theTNF molecule into a biologically active homotrimer.
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Use of the yeast three-hybrid system as a tool to study caspases.
Wim Van Criekinge,Maria van Gurp,Els Decoster,Peter Schotte,Marc Van de Craen,Walter Fiers,Peter Vandenabeele,Rudi Beyaert +7 more
TL;DR: The use of a yeast three-hybrids approach is described as a tool that adapts the classical two-hybrid system to the needs of heteromeric caspases for functional dissection of known interactions or screening for physiological substrates and inhibitors.
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