Ellen Heinemann
Max Planck Society
5 Papers
10 Citations
Ellen Heinemann is an academic researcher from Max Planck Society. The author has contributed to research in topics: Tuberculosis & Biology. The author has an hindex of 5, co-authored 5 publications.
Chat about Author
Papers
MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment.
Anca Dorhoi,Marco Iannaccone,Maura Farinacci,Kellen C. Faé,Jörg Schreiber,Pedro Moura-Alves,Geraldine Nouailles,Hans-Joachim Mollenkopf,Dagmar Oberbeck-Müller,Sabine Jörg,Ellen Heinemann,Karin Hahnke,Delia Löwe,Franca Del Nonno,Delia Goletti,Rosanna Capparelli,Stefan H. E. Kaufmann +16 more
TL;DR: It is concluded that miR-223 directly targets the chemoattractants CXCL2, CCL3, and IL-6 in myeloid cells, and consequently, neutrophil-driven lethal inflammation in TB animals.
Type I IFN signaling triggers immunopathology in tuberculosis‐susceptible mice by modulating lung phagocyte dynamics
Anca Dorhoi,Vladimir Yeremeev,Geraldine Nouailles,January Weiner,Sabine Jörg,Ellen Heinemann,Dagmar Oberbeck-Müller,Julia K. Knaul,Alexis Vogelzang,Stephen T. Reece,Karin Hahnke,Hans-Joachim Mollenkopf,Volker Brinkmann,Stefan H. E. Kaufmann +13 more
TL;DR: It is concluded that IFN I alters early innate events at the site of Mtb invasion leading to fatal immunopathology, furnish a mechanistic explanation for the detrimental role of IFn I in pulmonary TB and form a basis for understanding the complex roles ofIFN I in chronic inflammation.
202
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis.
Anca Dorhoi,Geraldine Nouailles,Sabine Jörg,Kristine Hagens,Ellen Heinemann,Lydia Pradl,Dagmar Oberbeck-Müller,María A. Duque-Correa,Stephen T. Reece,Jürgen Ruland,Roland Brosch,Jürg Tschopp,Olaf Gross,Stefan H. E. Kaufmann +13 more
TL;DR: During TB, Mycobacterium tuberculosis promotes NLRP3‐ and caspase‐1‐independent IL‐1β release in myeloid cells recruited to lung parenchyma and thus overcomesNLRP3 deficiency in vivo in experimental models.
174
Regional IFNgamma expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier.
Nadesan Gajendran,Hans-Willi Mittrücker,Karin Bordasch,Ellen Heinemann,Markus Koch,Stefan H. E. Kaufmann +5 more
TL;DR: This model indicates that local IFNgamma expression by non-immunological cells in the distal part of the small intestine, caecum and colon is insufficient for prevention of gut penetration by S. enterica Typhimurium and L. monocytogenes.
10
Lung-Residing Myeloid-derived Suppressors Display Dual Functionality in Murine Pulmonary Tuberculosis
Julia K. Knaul,Sabine Jörg,Dagmar Oberbeck-Mueller,Ellen Heinemann,Lisa Scheuermann,Volker Brinkmann,Hans-Joachim Mollenkopf,Vladimir Yeremeev,Stefan H. E. Kaufmann,Anca Dorhoi +9 more
TL;DR: It is revealed that MDSCs provide a niche for pathogen survival and tailor immunity in TB, and are suggested as amenable targets for host-directed therapies and emphasize them as cellular-immune regulators during chronic inflammatory conditions.