Ellen Doney

TL;DR: Investigating how chronic social or variable stress, two mouse models of depression, impact the jejunum (JEJ) intestinal barrier in males and females provides evidence that chronic stress disrupts intestinal barrier homeostasis in conjunction with the manifestation of depressive-like behaviors in a sex-specific manner in mice and possibly, human depression.

TL;DR: The CCNP 2020 Young Investigator Award recipient as mentioned in this paper characterized the enduring changes in histone modifications in the NAcc of mice exposed to chronic social defeat stress (CSDS), a validated model for the study of depression-like behaviours that separates mouse populations into susceptible (SUS) and resilient (RES) based on a social interaction test (SIT).

TL;DR: The challenges, pros, and cons of recent advances in super-resolution microscopy techniques are summarized, hoping that a growing number of scientists will integrate them in their study design exploring barrier-related properties and mechanisms.