Ella Magal
Amgen
23 Papers
503 Citations
Ella Magal is an academic researcher from Amgen. The author has contributed to research in topics: Glial cell line-derived neurotrophic factor & Spiral ganglion. The author has an hindex of 15, co-authored 23 publications.
Chat about Author
Papers
Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise trauma
Jukka Ylikoski,Ulla Pirvola,Jussi Virkkala,P Suvanto,X.-Q Liang,Ella Magal,Richard A. Altschuler,Josef M. Miller,Mart Saarma +8 more
TL;DR: The results demonstrate that GDNF is likely to be an endogeneous survival factor in the normal mammalian cochlea and it could have application as a pharmacological treatment to prevent secondary auditory nerve degeneration following organ of Corti damage.
203
Rescue and regrowth of sensory nerves following deafferentation by neurotrophic factors.
Richard A. Altschuler,Richard A. Altschuler,Younsook Cho,Younsook Cho,Jukka Ylikoski,Ulla Pirvola,Ella Magal,Josef M. Miller +7 more
TL;DR: Study in the cochlea show that application of exogenous neurotrophic factors can enhance survival of spiral ganglion cells after deafness and induce regrowth of peripheral processes, perhaps by replacing lost endogenous factors.
Glial cell line-derived neurotrophic factor has a dose dependent influence on noise-induced hearing loss in the guinea pig cochlea.
Fumi Shoji,Tatsuya Yamasoba,Tatsuya Yamasoba,Ella Magal,David F. Dolan,Richard A. Altschuler,Josef M. Miller +6 more
TL;DR: It is indicated that GDNF at certain concentrations can effectively protect the inner ear from noise-induced hearing loss.
87
Patent
Eck receptor ligands
Timothy D. Bartley,William J. Boyle,Gary M. Fox,Andrew A. Welcher,Ella Magal,Richard A. Lindberg,Vann P. Parker +6 more
- 15 Nov 1993
TL;DR: In this paper, the binding properties of polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding them are disclosed.
46
Glial Cell Line‐Derived Neurotrophic Factor: Potential for Otoprotection
R. Kuang,G. Hever,Gary Zajic,Qiao Yan,F. Collins,J.-C. Louis,Elizabeth M. Keithley,Ella Magal +7 more
TL;DR: The number of surviving hair cells in GDNF‐treated ears was about twice that of control ears in animals exposed to the ototoxins, and the efficacy of GDNF in animal models of ototoxicity was tested next.
44