Elizabeth McLaughlin-Taylor
University of Southern California
6 Papers
63 Citations
Elizabeth McLaughlin-Taylor is an academic researcher from University of Southern California. The author has contributed to research in topics: Antigen & Major histocompatibility complex. The author has an hindex of 4, co-authored 6 publications.
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Papers
Creation of H-2 class I epitopes using synthetic peptides: recognition by alloreactive cytotoxic T lymphocytes.
TL;DR: It is shown that the recognition of a particular class I molecule by a bulk population of alloreactive CTLs can be altered by incubating with it a peptide derived from anotherclass I molecule, suggesting that peptide binding is an important function of class I molecules.
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Cloning and identification of the H-2Dp gene.
Mary J. Macchi,Jerold G. Woodward,Elizabeth McLaughlin-Taylor,Johanna Griffin,Johanna Griffin,Leroy Hood,Jeffrey A. Frelinger,Jeffrey A. Frelinger +7 more
TL;DR: Six different class I genes from a B10.P sperm library are cloned and Kp-specific monoclonal antibodies are identified, confirmed by mapping a 2.5 kb Bam H 1 restriction fragment present in the λ12a DNA clone to the D-TL region of H-2p.
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Functional characterization of the H-2Dp gene product.
Elizabeth McLaughlin-Taylor,Jerold G. Woodward,Mary J. Macchi,Minnie McMillan,Jeffrey A. Frelinger,Jeffrey A. Frelinger +5 more
TL;DR: Lymphocytic choriomeningitis virus (LCMV) killer T cells from B 10.P mice were able to kill LCMV-infected L12a cells, but not LCMv- Infected Ltk+.
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Distinct epitopes are recognized by cytolytic T lymphocyte clones on the same class I molecule: direct demonstration using DNA‐transfected targets and longterm cytolytic T cell clones
Elizabeth McLaughlin-Taylor,Jerold G. Woodward,Minnie McMillan,Jeffrey A. Frelinger,Jeffrey A. Frelinger +4 more
TL;DR: By producing long‐term, stable, cytolytic T lymphocyte clones and utilizing targets expressing only a single gene product derived from the stimulator mouse strain, this work has been able to directly demonstrate that T cells recognize distinct epitopes expressed on a single H‐2 molecule.
7
Expression in L cells of transfected class I genes from the mouse major histocompatibility complex
Brian S. Schepart,Jerold G. Woodward,Melanie J. Palmer,Mary J. Macchi,Patricia V. Basta,Elizabeth McLaughlin-Taylor,Jeffrey A. Frelinger +6 more
TL;DR: It is reported that these non-K/D genes can provoke antibody responses and be recognized by cytolytic T cells and can be expressed by L cells.
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