Elizabeth E. Eynon
Yale University
33 Papers
208 Citations
Elizabeth E. Eynon is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & Biology. The author has an hindex of 20, co-authored 33 publications. Previous affiliations of Elizabeth E. Eynon include Bill & Melinda Gates Foundation & Howard Hughes Medical Institute.
Chat about Author
Papers
Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine
Anthony Rongvaux,Hitoshi Takizawa,Till Strowig,Tim Willinger,Elizabeth E. Eynon,Richard A. Flavell,Richard A. Flavell,Markus G. Manz +7 more
TL;DR: The fundamental requirements and the remarkable progress made over the past few years in improving these models are reviewed, the current major achievements reached by use of these models, and the future challenges to more closely model and study human health and disease are reviewed.
Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung
Tim Willinger,Anthony Rongvaux,Hitoshi Takizawa,George D. Yancopoulos,David Valenzuela,Andrew J. Murphy,Wojtek Auerbach,Elizabeth E. Eynon,Sean Stevens,Markus G. Manz,Richard A. Flavell +10 more
TL;DR: It is demonstrated that hIL-3/GM-CSF KI mice engrafted with human CD34+ hematopoietic cells had improved human myeloid cell reconstitution in the lung and mounted correlates of a human innate immune response against influenza virus.
249
Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.
Till Strowig,Anthony Rongvaux,Chozhavendan Rathinam,Hitoshi Takizawa,Hitoshi Takizawa,Chiara Borsotti,Chiara Borsotti,William M. Philbrick,Elizabeth E. Eynon,Elizabeth E. Eynon,Markus G. Manz,Markus G. Manz,Richard A. Flavell,Richard A. Flavell +13 more
TL;DR: HSIRPa-transgenic Rag2/−γc−/− mice represent a unique mouse strain supporting high levels of human cell engraftment, which can easily be genetically manipulated and improved functionality of the human immune system in these mice.
243
Humanized mice for modeling human infectious disease: challenges, progress, and outlook.
Nicolas Legrand,Nicolas Legrand,Alexander Ploss,Alexander Ploss,Rudi Balling,Pablo D. Becker,Chiara Borsotti,Nicolas Brezillon,Nicolas Brezillon,Jennifer Debarry,Ype P. de Jong,Ype P. de Jong,Hongkui Deng,Hongkui Deng,James P. Di Santo,James P. Di Santo,Stephanie C. Eisenbarth,Stephanie C. Eisenbarth,Elizabeth E. Eynon,Elizabeth E. Eynon,Richard A. Flavell,Richard A. Flavell,Carlos A. Guzmán,Nicholas D. Huntington,Nicholas D. Huntington,Dina Kremsdorf,Dina Kremsdorf,Michael Manns,Michael Manns,Markus G. Manz,Jean Jacques Mention,Jean Jacques Mention,Michael Ott,Michael Ott,Chozhavendan Rathinam,Chozhavendan Rathinam,Charles M. Rice,Charles M. Rice,Anthony Rongvaux,Anthony Rongvaux,Sean Stevens,Sean Stevens,Hergen Spits,Hergen Spits,Hélène Strick-Marchand,Hélène Strick-Marchand,Hitoshi Takizawa,Anja U. van Lent,Anja U. van Lent,Chengyan Wang,Chengyan Wang,Kees Weijer,Kees Weijer,Tim Willinger,Tim Willinger,Patrick Ziegler +55 more
TL;DR: The potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases, are discussed.
233
Local Expression of TNFα in Neonatal NOD Mice Promotes Diabetes by Enhancing Presentation of Islet Antigens
TL;DR: It is demonstrated that islet-specific expression of TNFalpha in neonatal nonobese diabetic mice accelerated diabetes and inflammation can trigger autoimmunity by recruiting and activating dendritic cells/macrophages to present self-antigens to autoreactive T cells.
203