Elisabet Frithz-Lindsten
Umeå University
11 Papers
273 Citations
Elisabet Frithz-Lindsten is an academic researcher from Umeå University. The author has contributed to research in topics: Secretion & Type three secretion system. The author has an hindex of 8, co-authored 11 publications.
Chat about Author
Papers
The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation :
Jonas Pettersson,Anna Holmström,Jim Hill,Sophie Emma Clare Leary,Elisabet Frithz-Lindsten,Anne von Euler-Matell,Eva Carlsson,Richard W. Titball,Åke Forsberg,Hans Wolf-Watz +9 more
TL;DR: It is shown that anti‐LcrV antibodies can block the delivery of Yop effectors into the target cell cytosol, suggesting that LcrV serves an important role in the initiation of the translocation process and provides one possible explanation for the mechanism of LCrV‐induced protective immunity.
246
Intracellular targeting of exoenzyme S of Pseudomonas aeruginosa via type III‐dependent translocation induces phagocytosis resistance, cytotoxicity and disruption of actin microfilaments
TL;DR: The data suggest that P. aeruginosa, by analogy with Yersinia, targets virulence proteins into the eukaryotic cytosol via a type III secretion‐dependent mechanism as part of an anti‐phagocytic strategy.
232
The chaperone-like protein YerA of Yersinia pseudotuberculosis stabilizes YopE in the cytoplasm but is dispensible for targeting to the secretion loci
TL;DR: The virulence plasmid‐encoded YopE cytotoxin of Yersinia pseudotuberculosis is secreted across the bacterial membranes and subsequently translocated into the eukaryotic cell.
136
Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis
Anna-Lena Forslund,Kerstin Kuoppa,Kerstin Svensson,Emelie Salomonsson,Anders Johansson,Mona Byström,Petra C. F. Oyston,Stephen L. Michell,Richard W. Titball,Richard W. Titball,Laila Noppa,Elisabet Frithz-Lindsten,Mats Forsman,Åke Forsberg +13 more
TL;DR: It is established that repeat‐mediated loss of one of the putative pilin genes in a type B strain results in severe virulence attenuation in mice infected by subcutaneous route and indicates that this putative Pilin is critical for Francisella infections that occur via peripheral routes.
114
Functional conservation of the effector protein translocators PopB/YopB and PopD/YopD of Pseudomonas aeruginosa and Yersinia pseudotuberculosis
Elisabet Frithz-Lindsten,Anna Holmström,Lars Jacobsson,Mehnam Soltani,Jan Olsson,Roland Rosqvist,Åke Forsberg +6 more
TL;DR: The findings show that the contact‐dependent toxin‐targeting mechanisms of Y. pseudotuberculosis and P. aeruginosa are conserved at the molecular level and that the translocator proteins are functionally interchangeable.
107