Elisa Meroni
Katholieke Universiteit Leuven
15 Papers
8 Citations
Elisa Meroni is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & Colitis. The author has an hindex of 5, co-authored 9 publications.
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Papers
Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons
Nathalie Stakenborg,Evelien Labeeuw,Pedro J. Gomez-Pinilla,Sebastiaan De Schepper,Raymond Aerts,Gera Goverse,Giovanna Farro,Iris Appeltans,Elisa Meroni,Michelle Stakenborg,Maria Francesca Viola,Erika Gonzalez-Dominguez,Goele Bosmans,Yeranddy A. Alpizar,Albert Wolthuis,André D'Hoore,Kim Van Beek,Simon Verheijden,Marleen Verhaegen,Rita Derua,Etienne Waelkens,Milena Moretti,Cecilia Gotti,Patrick Augustijns,Karel Talavera,Pieter Vanden Berghe,Gianluca Matteoli,Guy E. Boeckxstaens +27 more
TL;DR: Preoperative, but not postoperative treatment with prucalopride prevents intestinal inflammation and shortens POI in both mice and human, indicating that preoperative administration of 5-HT4R agonists should be further evaluated as a treatment of POI.
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CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus
Giovanna Farro,Michelle Stakenborg,Pedro J. Gomez-Pinilla,Evelien Labeeuw,Gera Goverse,Martina Di Giovangiulio,Nathalie Stakenborg,Elisa Meroni,Francesca D'Errico,Yvon Elkrim,Damya Laoui,Zofia M. Lisowski,Kristin A. Sauter,David A. Hume,Jo A. Van Ginderachter,Guy E. Boeckxstaens,Gianluca Matteoli +16 more
TL;DR: A critical role for monocyte-derived MΦs in restoring intestinal homeostasis after surgical trauma is revealed, indicating that inappropriate targeting of monocytes may increase neutrophil-mediated immunopathology and prolong the clinical outcome of POI, while future therapies should be aimed at enhancing M Φ physiological repair functions.
Intestinal macrophages and their interaction with the enteric nervous system in health and inflammatory bowel disease.
TL;DR: This review discusses recent insights on the cross‐talk between enteric neurons and the immune system, especially focusing on macrophages, and provides an overview of basic and translational aspects of the cholinergic anti‐inflammatory response as therapeutic alternative to reinstall immune homoeostasis in intestinal chronic inflammation.
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Functional characterization of oxazolone-induced colitis and survival improvement by vagus nerve stimulation.
Elisa Meroni,Nathalie Stakenborg,Pedro J. Gomez-Pinilla,Gert De Hertogh,Gera Goverse,Gianluca Matteoli,Simon Verheijden,Guy E. Boeckxstaens +7 more
TL;DR: Oxazolone-induced colitis rather represents a model of sepsis and, at best, may resemble a severe type of ulcerative colitis, associated with early and severe mucosal damage and a high mortality rate.
Vagotomy affects the development of oral tolerance and increases susceptibility to develop colitis independently of the alpha-7 nicotinic receptor.
Martina Di Giovangiulio,Goele Bosmans,Elisa Meroni,Nathalie Stakenborg,Morgane Florens,Giovanna Farro,Pedro J. Gomez-Pinilla,Gianluca Matteoli,Guy E. Boeckxstaens +8 more
TL;DR: A key role is indicated for the vagal intestinal innervation in the development of oral tolerance and colitis, most likely by modulating induction of Tregs independently of α7nAChR.