https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-6143.2004.00406.x

Acute Graft Versus Host Disease Following Liver Transplantation: The Enemy Within

BackgroundGraft-versus-host-disease (GVHD) after liver transplantation (LT) is a deadly complication with very limited data on risk factors, diagnosis and management. We report a case series and a comprehensive review of the literature.MethodsData were systematically extracted from reports of GVHD a

/pdf/graft-versus-host-disease-after-liver-transplantation-in-2jpq5w32r3.pdf

Graft Versus Host Disease after Liver Transplantation in Adults: A Case series, Review of Literature, and an Approach to Management

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/lt.21203

Graft vs. host disease after liver transplantation: a new approach is needed.

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/lt.21082

Recipient and donor factors influence the incidence of graft-vs.-host disease in liver transplant patients.

Graft-vs-host disease (GVHD) is an uncommon complication of solid organ transplantation Herein, we report a case of GVHD occurring in a lung transplant recipient and review 29 reported cases of GVHD that complicated thoracic organ, and non-hepatic intra-abdominal organ transplantation The major presenting clinical symptom of GVHD was skin rash Less frequent clinical manifestations were cytopenia (16%), diarrhea (11%), and fever (5%) The mainstay of treatment was high-dose corticosteroids The mortality rate was high (30%) The cause of death was mainly due to infection, suggesting that antimicrobial prophylaxis may improve the outcome of this potentially fatal complication

Graft-vs.-host disease in lung and other solid organ transplant recipients.

We report herein the case of a patient who developed fatal acute graft-versus host disease (GvHD) after liver transplantation (LT). GvHD occurred 18 days after LT and was characterized by skin epidermolysis, diarrhea and leucopenia. Skin biopsy showed epidermal dyskeratosis with epithelial necrosis, a lesion consistent with GvHD. Despite immunosuppressive therapy, the patient died within 24 days. In our observation, GvHD occurred although five HLA compatibilities were identified between the donor and the recipient, an apparently favorable and uncommon situation. This case further supports the qualification that LT may be complicated by GvHD and strongly suggests that minor rather than major histocompatibility antigens are the main target of allogenic interactions of GvHD. The involvement of chimerism in GvHD is controversial and requires further investigation.

Lethal acute graft-versus-host disease in a liver transplant recipient: relations with cell migration and chimerism.

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Lethal acute graft-versus-host disease in a liver transplant recipient: relations with cell migration and chimerism.