Elena I. Frolova
University of Alabama at Birmingham
124 Papers
603 Citations
Elena I. Frolova is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Alphavirus & Viral replication. The author has an hindex of 37, co-authored 111 publications. Previous affiliations of Elena I. Frolova include University of Texas Medical Branch & University of Alabama.
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Papers
New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes
Dal Young Kim,Josephine M. Reynaud,Aliaksandra Rasalouskaya,Ivan Akhrymuk,James A. Mobley,Ilya Frolov,Elena I. Frolova +6 more
TL;DR: It is shown that distantly related New World and Old World alphaviruses have independently evolved to utilize different cellular stress granule-related proteins for assembly of complexes, which recruit viral genomic RNA and facilitate formation of viral replication complexes (vRCs).
Inhibition of Transcription and Translation in Sindbis Virus-Infected Cells
TL;DR: It is demonstrated that downregulation of transcription of all of the cellular mRNAs appears to be a very efficient means of reducing the development of an antiviral response, and that the ability to cause transcriptional shutoff may partially determine SIN host range and replication in particular tissues.
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Different Types of nsP3-Containing Protein Complexes in Sindbis Virus-Infected Cells
TL;DR: It is suggested that Sindbis virus (SINV) infection in BHK-21 cells leads to the formation of at least two types of nsP3-containing complexes, one of which was found in association with the plasma membrane and endosome-like vesicles, while the second was coisolated with cell nuclei.
145
New PARP Gene with an Anti-Alphavirus Function
TL;DR: A noncytopathic Venezuelan equine encephalitis virus (VEEV) mutant is developed that can persistently replicate in cells defective in type I interferon (IFN) production or signaling but is cleared from IFN signaling-competent cells and demonstrates an inhibitory effect on the replication of VEEV.
140
Sindbis virus replicons and Sindbis virus: assembly of chimeras and of particles deficient in virus RNA.
TL;DR: The studies described here were designed to prevent recombination by expressing the capsid protein from one DH RNA and the virus membrane proteins from a second helper RNA, which resulted in the high-level production of particles that were almost completely devoid of RNA.
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