Elena Grabski
Hannover Medical School
17 Papers
60 Citations
Elena Grabski is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Virus & Hepatitis C virus. The author has an hindex of 11, co-authored 16 publications.
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Papers
Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis.
Chintan Chhatbar,Claudia N. Detje,Elena Grabski,Katharina Borst,Julia Spanier,Luca Ghita,David A. Elliott,Marta Joana Costa Jordão,Nora Mueller,James Sutton,Chittappen K. Prajeeth,Viktoria Gudi,Michael A. Klein,Marco Prinz,Frank Bradke,Martin Stangel,Ulrich Kalinke +16 more
TL;DR: In the infected CNS, the cross talk among neurons, astrocytes, andmicroglia is critical for full microglia activation and protection from lethal encephalitis.
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Morbillivirus Control of the Interferon Response: Relevance of STAT2 and mda5 but Not STAT1 for Canine Distemper Virus Virulence in Ferrets
Nicholas Svitek,Ingo Gerhauser,Ingo Gerhauser,Christophe Goncalves,Elena Grabski,Marius Döring,Ulrich Kalinke,Danielle E. Anderson,Roberto Cattaneo,Veronika von Messling,Veronika von Messling,Veronika von Messling +11 more
TL;DR: This study demonstrates the importance of interference with STAT2 and mda5 signaling for CDV immune evasion and provides a starting point for the development of morbillivirus vectors with reduced immunosuppressive properties.
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Constant TCR triggering suggests that the TCR expressed on intestinal intraepithelial γδ T cells is functional in vivo
Frano H. Malinarich,Elena Grabski,Tim Worbs,Vijaykumar Chennupati,Jan D. Haas,Susanne Schmitz,Enzo Candia,Rodrigo Quera,Bernard Malissen,Reinhold Förster,Marcela A. Hermoso,Immo Prinz +11 more
TL;DR: In vivo blocking of the γδ TCR with specific mAb led to a decrease of basal calcium levels in CD8αα+ γ δ iIEL, suggesting that the TCR of CD8 αα+ £1,000-2,000 is constantly being triggered and therefore functional in vivo.
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A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance
Hui Wang,Souhayla El Maadidi,Janett Fischer,Elena Grabski,Sabine Dickhöfer,Sascha N. Klimosch,Sinead M. Flannery,Angela Filomena,Olaf Oliver Wolz,Nicole Schneiderhan-Marra,Markus W. Löffler,Manfred Wiese,Tica Pichulik,Beat Müllhaupt,David Semela,Jean-François Dufour,Pierre-Yves Bochud,Andrew G. Bowie,Ulrich Kalinke,Thomas Berg,Alexander N.R. Weber +20 more
TL;DR: This study discovered a comparatively frequent coding variant of the enigmatic human IRAK2, L392V, to be associated with a reduced ability to induce interferon‐alpha in primary human plasmacytoid dendritic cells in response to hepatitis C virus (HCV).
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