Elena Abbotto
University of Genoa
7 Papers
Elena Abbotto is an academic researcher from University of Genoa. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications.
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Papers
Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling
Sneha Mishra,Claudia Cosentino,Ankit Kumar Tamta,Danish Khan,Shalini Srinivasan,Venkatraman Ravi,Elena Abbotto,Bangalore Prabhashankar Arathi,Shweta Kumar,Aditi Jain,Anand S Ramaian,Shruti M. Kizkekra,Raksha Rajagopal,Swathi K. Rao,Swati Krishna,Ninitha Asirvatham-Jeyaraj,Elizabeth R. Haggerty,Dafne Magalí Silberman,Irwin J. Kurland,Ravindra P. Veeranna,Tamilselvan Jayavelu,Santina Bruzzone,Raul Mostoslavsky,Nagalingam R. Sundaresan +23 more
TL;DR: In this paper , SIRT6, a chromatin-associated deacetylase indirectly regulates glucocorticoid-induced muscle wasting by modulating IGF/PI3K/AKT signaling.
Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage
Annarita Nappi,Caterina Miro,Antonio Pezone,Alfonso Tramontano,Emery Di Cicco,Serena Sagliocchi,Annunziata Gaetana Cicatiello,Melania Murolo,Sepehr Torabinejad,Elena Abbotto,Giuseppina Caiazzo,Maddalena Raia,Mariano Stornaiuolo,Dario Antonini,Gabriella Fabbrocini,Domenico Salvatore,Vittorio Enrico Avvedimento,Monica Dentice +17 more
TL;DR: In this paper , the authors show that the cell stress sensor and tumor suppressor p53 silences D2 expression, thereby lowering the intracellular THs availability, and even partial loss of p53 elevates D2/TH resulting in stimulation and increased fitness of tumor cells by boosting a significant transcriptional program.
Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays
Elena Abbotto,Beatrice Casini,Francesco Piacente,Naomi Scarano,Elena Cerri,Michele Tonelli,Cecilia Astigiano,Enrico Millo,Laura Sturla,Santina Bruzzone,Elena Cichero +10 more
TL;DR: A small in-house library of compounds (1a–7a), previously investigated as putative HSP70 inhibitors, was described to guide the search for dual-acting H SP70/SIRT2 inhibitors and 2a and 7a were found to be the most promising derivatives herein proposed.
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Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors
Naomi Scarano,Elena Abbotto,Francesca Musumeci,Annalisa Salis,Chiara Brullo,Paola Fossa,Silvia Schenone,Santina Bruzzone,Elena Cichero +8 more
TL;DR: In this paper , the authors reported preliminary Structure-Based Virtual Screening (SBVS) studies using a commercially available library of compounds to identify novel scaffolds for the design of new SIRT2 inhibitors.
SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma.
Elena Abbotto,Caterina Miro,Francesco Piacente,Annalisa Salis,Melania Murolo,Annarita Nappi,Enrico Millo,E. Russo,Elena Cichero,Laura Sturla,Alberto Del Rio,A. Flora,Alessio Nencioni,Monica Dentice,Santina Bruzzone +14 more
- 21 Aug 2023
TL;DR: It is confirmed that SIRT6 plays a role in skin carcinogenesis and pharmacological inhibition is suggested as a promising strategy in cSCC and in a DMBA-TPA-induced skin cancer mouse model.