Eleanor M. Wigmore
University of Edinburgh
26 Papers
134 Citations
Eleanor M. Wigmore is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Major depressive disorder & Genome-wide association study. The author has an hindex of 13, co-authored 23 publications. Previous affiliations of Eleanor M. Wigmore include Royal Edinburgh Hospital & AstraZeneca.
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Papers
Genetic Analysis Identifies a Novel Missense Variant in SPDL1 Associated with Idiopathic Pulmonary Fibrosis
Johan Mattsson,Kristina Ibáñez,Eleanor M. Wigmore,Quanli Wang,Glenda Lassi,Louise V. Wain,Richard J. Allen,Susan J. Monkley,Maria Karlsson,Henric Olsson,Daniel Muthas,A. Mackay,Lynne Murray,Carolina Haefliger,Simon Young,Toby M. Maher,Maria G. Belvisi,Gisli Jenkins,P.L. Molyneaux,Adam Platt,Slavé Petrovski +20 more
- 01 May 2020
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AZD4625 is a Potent and Selective Inhibitor of KRASG12C
Atanu Chakraborty,Lyndsey Hanson,David A. Robinson,Hilary J. Lewis,Susan J. Bickerton,Michael Davies,Radoslaw Polanski,Rebecca Whiteley,Alexander Koers,James B. Atkinson,Tamara Baker,Ivan del Barco Barrantes,Giovanni Ciotta,Jason Grant Kettle,Lukasz Magiera,Carla Martins,Alison Peter,Eleanor M. Wigmore,Zoe Elizabeth Underwood,Sabina Cosulich,Michael J. Niedbala,Sarah Ross +21 more
TL;DR: The pharmacology of AZD4625 shows that it has the potential to provide therapeutic benefit to patients with KRASG12C mutant cancer as either a monotherapy treatment or in combination with other targeted drug agents.
Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank
Lynsey S. Hall,Mark Adams,Aleix Arnau-Soler,Toni-Kim Clarke,David M. Howard,Yanni Zeng,Gail Davies,Saskia P. Hagenaars,Ana Maria Fernandez-Pujals,Jude Gibson,Eleanor M. Wigmore,Thibaud Boutin,Caroline Hayward,Generation Scotland,David J. Porteous,Ian J. Deary,Pippa A. Thomson,Chris Haley,Andrew M. McIntosh +18 more
TL;DR: While stratified GWAS analysis revealed a genome-wide significant locus for male MDD, the lack of independent replication, the equivalent SNP-based heritability estimates and the consistent pattern of genetic correlation with other health-related traits suggests that phenotypic stratification in currently available sample sizes is currently weakly justified.
Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways
David M. Howard,Mark Adams,Masoud Shirali,Toni-Kim Clarke,Riccardo E. Marioni,Gail Davies,Jonathan R. I. Coleman,Clara Alloza,Xueyi Shen,Miruna C. Barbu,Eleanor M. Wigmore,Saskia P. Hagenaars,Cathryn M. Lewis,Daniel J. Smith,Patrick Sullivan,Chris Haley,Gerome Breen,Ian J. Deary,Andrew M. McIntosh +18 more
TL;DR: A genome-wide association study in the largest single population-based cohort to date, UK Biobank, provides a number of novel genetic risk variants that can be leveraged to elucidate the mechanisms of MDD and low mood.
Impact of Polygenic Risk for Schizophrenia on Cortical Structure in UK Biobank.
Emma Neilson,Xueyi Shen,Simon R. Cox,Toni-Kim Clarke,Eleanor M. Wigmore,Jude Gibson,David M. Howard,Mark Adams,Harris Ma,Gail Davies,Ian J. Deary,Heather C. Whalley,Andrew M. McIntosh,Stephen M. Lawrie +13 more
TL;DR: Results suggest that individual differences in CT are partly influenced by genetic variants and are most likely not due to factors downstream of disease onset, and may help to elucidate the genetic pathophysiology of schizophrenia.