Elaine Kwan
University of Toronto
4 Papers
Elaine Kwan is an academic researcher from University of Toronto. The author has contributed to research in topics: Risk factor & Breast cancer. The author has an hindex of 4, co-authored 4 publications.
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Papers
Contribution of BRCA1 and BRCA2 mutations to breast and ovarian cancer in Pakistan
Alexander Liede,Alexander Liede,Imtiaz A. Malik,Zeba Aziz,Patricia de los Rios,Elaine Kwan,Steven A. Narod +6 more
TL;DR: The results suggest that recessively inherited genes may contribute to breast and ovarian cancer risk in Pakistan.
176
Classification of BRCA1 missense variants of unknown clinical significance
Catherine M. Phelan,V. Dapic,B. Tice,Reyna Favis,Elaine Kwan,Francis Barany,Siranoush Manoukian,Paolo Radice,R. B. van der Luijt,B. P. M. Van Nesselrooij,Georgia Chenevix-Trench,kConFab,Trinidad Caldés,M. De La Hoya,S. Lindquist,Sean V. Tavtigian,David E. Goldgar,Åke Borg,Steven A. Narod,Alvaro N.A. Monteiro +19 more
TL;DR: A combination of several methods provides a more powerful way of identifying variants that are causally linked to a high risk of breast and ovarian cancer.
105
The Exon 13 Duplication in the BRCA1 Gene Is a Founder Mutation Present in Geographically Diverse Populations
Sylvie Mazoyer,J. Leary,Judy Kirk,E. Fleischmann,Teresa Wagner,Kathleen Claes,Ludwine Messiaen,William D. Foulkes,M. Desrochers,Jacques Simard,Catherine M. Phelan,Elaine Kwan,Steven A. Narod,Pia Vahteristo,Heli Nevanlinna,X. Durando,Yves-Jean Bignon,Jean-Philippe Peyrat,C. Bonnardel,Olga M. Sinilnikova,N. Puget,Gilbert M. Lenoir,C. Audoynaud,David E. Goldgar,Christine Maugard,V. Caux,Sophie Gad,Dominique Stoppa-Lyonnet,Catherine Noguès,R. Lidereau,C. Machavoine,Brigitte Bressac-de Paillerets,B. Kuschel,B. Betz,Dieter Niederacher,M. W. Beckmann,Ute Hamann,SA Gayther,B. A.P. Ponder,M. Robinson,Graham R. Taylor,Tim Bishop,A. Catteau,Ellen Solomon,B. Cohen,M. Steel,N. Collins,M. Stratton,M. Van Der Looij,E. Olah,N. J. Miller,David E. Barton,R. S. Sverdlov,Eitan Friedman,Paolo Radice,M. Montagna,E. Sensi,Maria A. Caligo,R. van Eijk,Peter Devilee,R. B. van der Luijt,Ketil Heimdal,Pål Møller,Åke Borg,Orland Diez,J. Cortes,M. Domenech,Montserrat Baiget,A. Osorio,Javier Benitez,P. Maillet,A. P. Sappino,Hilal Özdağ,Tayfun Ozcelik,Mehmet Ozturk,Elizabeth M. Rohlfs,Jeff Boyd,Deborah McDermott,Kenneth Offit,Meredith A. Unger,Katherine L. Nathanson,Barbara L. Weber,Thomas A. Sellers,E. Hampton,Fergus J. Couch,Susan L. Neuhausen +85 more
TL;DR: The results demonstrate that it is strongly advisable, for laboratories carrying out screening either in English-speaking countries or in countries with historical links with Britain, to include within their BRCA1 screening protocols the polymerase chain reaction-based assay described in this report.
BRCA1 and BRCA2 mutations among breast cancer patients from the Philippines
Maria Lourdes De Leon Matsuda,Alexander Liede,Elaine Kwan,Cynthia A. Mapua,Eva Maria C. Cutiongco,Alex Tan,Åke Borg,Steven A. Narod +7 more
TL;DR: Germline mutations in the BRCA2 gene contribute more than mutations BRCa1 to breast cancer in the Philippines, due in large part to the presence of 2 common founder mutations.